The drug "Tyrozol": instructions for use, price, analogues and reviews about the drug. Is it possible to mix "Tyrozol" and alcohol?

What is the purpose of the preparation "Tyrozol"? Instructions on the use of this medication, its side effects and indications will be presented in detail in this article. In addition, we will tell you about whether this tool has contraindications to the use, in what form it is produced, what analogues exist and so on.

Form of release of a medicament and its composition

In what form does the preparation "Tyrozol" come on sale? Instructions for use of this product are always contained in the package along with the medicine.

Currently, the drug is available only in the form of round tablets of light yellow color (covered with a film membrane). This drug includes an active ingredient, such as thiamazole. In addition, the tablets also contain auxiliary components (sodium carboxymethyl starch, dimethicone 100, silicon dioxide colloid, hypromellose, lactose monohydrate, magnesium stearate, cellulose powder, talc, hypromellose, corn starch, titanium dioxide, macrogol 400, iron oxide yellow).

Pharmacological properties of the medicinal product

How does the medicine "Tyrozol" work? Instructions for use contains a lot of information on this. We will also consider it in the article presented.

The active substance of this drug is able to affect the thyroid gland, inhibiting the production of its hormones by blocking enzymes (for example, peroxidase, taking part in iodination of thyronin).

After taking the drug in the patient, the following changes are observed:

• Acceleration of the excretion of iodides from the thyroid gland and a decrease in basal metabolism;
• Increased activation of secretion and synthesis of thyroid - stimulating hormone by the pituitary gland (may be accompanied by a barely noticeable increase in the size of the thyroid gland).

It should also be noted that the treatment of thyrotoxicosis "Tyrosol" is very effective, especially with symptomatic therapy.

After a single intake of tablets, the duration of their action is about one day.

Indications for use of the drug

In what cases can a doctor prescribe a medicine "Tyrozol"? The instruction, which is attached to this preparation, contains a list of the following indications:

• Preparation for the therapy of thyrotoxicosis with the help of radioactive iodine;
• Thyrotoxicosis;
• Therapy in the latent period of action of radioactive iodine (conducted before the beginning of the action of the substance for 4-6 months);
• Preparation for surgical treatment of thyrotoxicosis (operation);
• Prevention of the disease after the appointment of iodine preparations (including after taking radiopaque iodine-containing drugs), if the patient has latent thyrotoxicosis, autonomic adenoma or thyrotoxicosis in the anamnesis.

It should also be mentioned that in exceptional cases the drug we are considering is used for long-term maintenance therapy of hyperthyroidism. As a rule, this happens when there is no possibility to perform radical treatment of the patient (for individual reasons or in connection with the general condition of the patient).

Contraindications to the use of medicament

Are there any conditions or pathologies in which it is forbidden to take "Tyrozol" medication? The instruction of the preparation gives an exhaustive answer to this question. It indicates the following contraindications for use:

• Increased sensitivity of the patient to an active substance such as thiamazole, and a thiourea derivative;
• Granulocytopenia, especially in the anamnesis;
• Agranulocytosis in the period of previous treatment with thiamazole or carbimazole;
• Cholestasis, manifested before the onset of therapy;
• Treatment with thiamozole in combination with the drug "Levothyroxine" during pregnancy.

It should also be noted that the presented remedy also has relative contraindications. These can include previously observed skin allergic reactions to thiourea derivatives.

Among other things, the drug should be used with extreme caution in patients who have very large goiter, accompanied by narrowing of the trachea. In this case, the patient is prescribed only short-term therapy during the preparation for surgery. It is also necessary to say that tablets "Tyrozol" should be taken with caution to patients with hepatic insufficiency. To prescribe a safe dosage of the drug, patients should always consult an experienced doctor.

"Tyrozol" medication and pregnancy

Few people know about this, but during pregnancy, you can take the drug. However, this should be done very carefully and only under the supervision of a doctor.

According to experts, the lack of proper treatment of such a deviation, as hyperthyroidism, during pregnancy can adversely affect the development of the fetus. Moreover, ignoring the disease will lead to serious complications (to premature birth, various abnormalities in the child, etc.).

Many women are interested in: the drug "Tyrozol" - a hormonal drug or not? The answer to this question is obvious. This medication is hormonal. It should be noted that it penetrates rather quickly through the placental barrier. Moreover, in the blood of a fetus, it can reach the same concentration as that of a future mother.

In view of the fact that the influence of the active ingredient (thiamazole) on the developing in utero organism can not be completely excluded, hormone tablets to pregnant women should be prescribed only after a full assessment of the risk and benefit of its use, in minimally effective dosages, without additional use of the drug "Levothyroxine".

The risk of using the drug "Tyrosol" in pregnancy

Every woman who has obvious thyroid problems should know how to take "Tyrosol" during the gestation period. This fact is due to the fact that the dosage of this drug, significantly exceeding the recommended one, can cause hypothyroidism and goiter in a future child, and also contribute to a low birth weight.

Lactation period

Is it possible to take the drug "Tyrozol" while breastfeeding? Analogues of this remedy, as well as the original itself, are not recommended during lactation. Why?

In view of the fact that the active substance thiamazole penetrates into the mother's milk rather quickly and is able to reach concentrations in it that correspond to that in the blood of a young mother, a newborn baby may develop such a deviation as hypothyroidism. In this regard, if it is necessary to continue the therapy of thyrotoxicosis during breast-feeding, the presented drug should be used in lower dosages (up to 10 mg in essence) without the addition of the drug "Levothyroxine".

The preparation "Tyrozol": instructions for use

If the doctor prescribes this medication to the patient, he is obliged to advise the patient about the peculiarities of its use. As a rule, the medicine is taken only after consumption of food. At the very beginning of therapy, experts recommend using the medication at a strictly certain time.

During treatment of thyrotoxicosis, patients usually receive 2-4 tablets of the drug per day (10 mg each). The duration of therapy should be at least 6 weeks.

After the function of the thyroid gland has been fully or partially restored, doctors recommend switching to a maintenance dose. In this case, patients need to take 5-20 mg of medication per day (concomitantly with the drug "Levothyroxine").

In preparation for thyrotoxicosis therapy with radioactive iodine, as well as for surgical intervention, patients are prescribed a similar dosage as in the usual treatment of the disease (up to the euthyroid status). After that, patients are additionally prescribed a medicine "Levothyroxine", beta-blockers and iodine preparations.

In the treatment, which is carried out before the onset of exposure to radioactive iodine, patients are prescribed a dosage equal to 1-4 tablets (5 mg each). Such a drug should be taken within a month.

In the course of long-term therapy (maintenance), the dosage of the drug, according to the instructions, is from 1.25 to 10 mg per day. At the same time, a small dose of Levothyroxine is prescribed.

In the preventive development of thyrotoxicosis during the period of taking iodine preparations, the drug "Tyrozol" is very effective at the following dosage: from 10 to 20 mg per day.

As a rule, this preparation is given to children based on body weight. Usually, as an initial dosage, the drug is prescribed in an amount of 0.3-0.5 mg. If supportive therapy is needed, the child should take 0.2-0.3 mg of the drug. In this case, the drug "Levothyroxine" is prescribed only in case of acute necessity.

The maximum single dose for adults is 10 ml, and the daily dose is 60 ml. The duration of taking the medication under consideration can be increased to 1.5-2 years (depending on the course of the disease). If the therapy was interrupted, then until the patient fully recovered, he may develop a relapse of the disease.

In rare cases, after the end of the drug, a person may experience late hypothyroidism, which is not a side effect, but is associated only with inflammatory and destructive processes occurring in the tissues of the thyroid gland.

Cases of overdose

The drug "Tyrozol" and weight gain: what is the relationship between them? In view of the fact that this drug is hormonal, it can directly affect the weight of the patient. However, most experts say the opposite. According to them, the "Tyrozol" medication and weight gain are not interrelated things. After all, the mass of a person who is diagnosed with thyrotoxicosis increases only because of the presence of the disease itself. Moreover, self abnormalities can cause strong edema on the face and extremities. In this case, you should consult a specialist and take tests for hormones.

If the patient has been prescribed the drug, then he needs to know about the way it is used. Indeed, in the case of an overdose of the drug in the patient may increase the thyroid gland, and also develop such a deviation as hypothyroidism. In these situations, the medicine is urgently canceled.

By the way, in high doses (more than 120 mg per day) this agent easily leads to the occurrence of myelotoxic effects.

Side effects after taking medication

What reactions can appear after using tablets "Tyrozol"? Side effects of this drug are described in each manual. Let's talk about them in more detail in this section of the article.

In most cases, the drug is tolerated fairly well by patients. However, it should be noted that sometimes during the reception of a medicine in people can develop allergic reactions to the skin (in the form of itching, redness and rashes) and arthralgia, in addition, in rare cases, dizziness, weakness and vomiting can occur.

What other negative consequences can the drug "Tyrozol" provoke? Side effects, reviews about this medication are presented in this section of the article. So, we are talking about such unpleasant reactions:

• Generalized lymphadenopathy;
• Thrombocytopenia;
• neuritis;
• temperature increase;
• Cholestatic jaundice, toxic hepatitis and arthralgia (develop very slowly);
• Autoimmune syndrome together with hypoglycemia;
• Marked increase in glands of salivary glands;
• Pancytopenia;
• Lupus-like reaction;
• Change in taste sensations of reversible nature;
• Agranulocytosis (manifested immediately or after several months from the start of therapy, which leads to the need to cancel the drug);
• Polyneuropathy.

According to reviews of those patients who are taking or have ever taken this medication, it can easily provoke an increase in body weight. As a rule, such a negative effect occurs after taking large doses of the drug.

When should I stop taking the drug?

Now you know how the drug "Tyrozol" can affect the human body. Side effects, which should immediately stop taking the drug, are as follows:

• Severe weakness;
• Generalized skin rash and itching;
• Difficulty swallowing;
• jaundice;
• Sore throat;
• Prolonged nausea or vomiting;
• Subcutaneous hemorrhage or bleeding of unknown origin;
• Signs of furunculosis or stomatitis;
• Severe pain in epigastrium.

Drug Interactions

The drug "Tyrozol" (the price is indicated below) produces a stronger effect with iodine deficiency, as well as during the simultaneous administration of such drugs as "Lithium", "Gentamicin", "Reserpy", "Amiodarone" and beta-blockers.

With therapy with this drug, the risk of developing leukopenia increases if you co-administer sulfonamides and metamizole sodium, and decreases with folic acid and leukogen.

There are no data on the effect of other drugs on the pharmacodynamics and pharmacokinetics of the drug presented to date. However, it should be remembered that with thyrotoxicosis, the patient is speeding up the elimination and metabolism of substances. In this regard, in a number of cases, a mandatory adjustment of the dose of other drugs is required.

Simultaneous reception of alcoholic beverages and medicinal product "Tyrozol"

How does the "Tyrozol" medication and alcohol interact, are they compatible or not? Asking such a question to any specialist, you immediately get an unambiguous answer.

The fact that alcoholic drinks contribute to the excitation of the brain and nervous system, regardless of whether a person is healthy or sick. After a joint intake of a medical preparation and alcohol, a synergistic effect takes place, which contributes to an increase in the negative impact of these substances on the body. As a result, additional side effects occur and pathological processes are stimulated.

That's why patients should remember that before the completion of drug treatment of thyroid diseases (as, indeed, any other) and achieving the desired result, no alcoholic beverages are out of the question.

Analogues of a medical product, reviews about the drug, its price and storage conditions

Now you know what the medicine "Tyrozol" is. The price of this drug may vary slightly depending on the mark-up of pharmacy chains. The average cost of such a drug is about 200 Russian rubles for 50 tablets.

What should I do if, for any reason, you could not get the medicine "Tyrozol"? Analogues of it (according to the active substance) are always available in the pharmacy. Among them, I would like to highlight the following drugs: "Mercazolil", "Tiamazol", "Metizol" and "Tiamazole-Philopharm". The price of these funds is similar to the above (in some pharmacies may be slightly different).

Important! According to the attached instructions, this medication belongs to a number of antithyroid medications. In this connection, the medicine is released only on the prescription form, on which there is a personal seal of the attending physician.

Judging by the opinions of patients, this remedy is quite effective. But this is only on condition that it is taken in the dosages prescribed by the doctor. In no case do not self-medicate and correct dosage at your own discretion - this is fraught with serious trouble. In order not to be unfounded, we give a few generalized comments of patients who have experienced this drug on themselves.

Often people complain of hair loss, discomfort in the pancreas, allergic reactions (severe itching and soreness of the skin), which appear after a few weeks of taking the drug "Tyrozol". Some patients mention an increase in the pulse rate. Pleased with a lot of complaints comes on nausea and pain in the stomach. Once again, recall that with the development of adverse reactions should stop taking the drug and see a doctor.

Keep the medicine preferably in a dark place, where direct sunlight does not reach. The shelf life of tablets is not more than 4 years.