The drug from hepatitis C "Sofosbuvir": reviews, instructions for use

The drug "Sofosbuvir" with the trade name "Sowaldi" allows to completely cure hepatitis C, while a positive result is achieved quickly enough, which is confirmed by clinical studies.

Medicinal preparation "Sofosbuvir" is treated with chronic form of hepatitis C. Complex therapy with the use of this drug and other medications is prescribed for adult patients. The drug also treats patients with HIV and co-infections.

The active component of the tablets is sophosbuvir. They are coated and contain 400 mg of the basic substance. The package contains 28 tablets.

Properties that are covered by the drug "Sofosbuvir"

The drug has a depressing effect on the NS5B RNA polymerase. As a result of its influence on the body, the process of replication of the virus is inhibited, which is the causative agent of hepatitis C.

Where to buy "Sofosbuvir" at an affordable price

The most useful information on how you can safely get your "course of recovery" is posted on thematic sites. The largest and most socially significant resource is HCV.RU - Russian-speaking hepatitis forum "at a stop," which was founded in 2000. As a rule, on serious portals all information is carefully checked by the administration and has a public evaluation.

If you do not take into account the forums, then one of the most interesting proposals, which we managed to find on the Internet, is called HCV24 ACCESS PROGRAM. More information about HCV24 services is available on the official website of the program.

Indications for use of the drug

The drug "Sofosbuvir" is prescribed for patients with hepatitis C when the disease has become chronic. A combined approach is used for the effectiveness of treatment. It is possible to use the medication in cases when the patient has HIV in addition to hepatitis.

Contraindications to the use of the drug "Sofosbuvir"

The drug is not used for hypersensitivity to substances that are present in its composition. Despite the fact that the drug has no effect on fertility, it is rarely prescribed to women in their reproductive years. The use of the drug during pregnancy and breast-feeding is not recommended, as it can be harmful to the child.

When a pregnancy occurs, the combination of Sofosbuvira with agents such as Interferon alfa and Ribavirin may have a negative effect on its course. For this reason, during the period of treatment, the child's bearing is undesirable. Experiments, during which the drug "Sofosbuvir" was tested in animals, showed that this drug has a slight negative impact on the offspring. Before you start taking it, you should carefully study the instructions for the drug and consult with a specialist.

Dosage of the drug "Sofosbuvir"

Treatment of "Sofosbuvir" hepatitis C chronic form can only be performed by those specialists who have relevant experience. Monotherapy is not done, the drug is always combined with other drugs. Often adults are recommended to take 400 mg (1 tablet) a day on a daily basis. The tablet is drunk while eating.

Therapy with Sofosbuvir from hepatitis C can last up to six months. Especially often such a need arises when there are some negative factors. The dose of the drug is selected taking into account the weight of the patient.

Combined treatment for hepatitis C:

• Genotypes 3-6 - to the main drug add "Interferon alfa" and "Ribavirin" (treatment takes more than three months);
• Genotypes 1, 4-6 - additionally apply "Interferon alfa" and "Ribavirin" for three months or only "Ribavirin" for six months (the second option is realized only if it is impossible to use the first method);
• Genotype 2 - the drug is combined with "Ribavirin", recovery usually comes after three months of using drugs.

If it is necessary to transplant the liver to a person who has hepatitis C, prescribe "Sofosbuvira" together with "Ribavirin" before it. During the period of therapy with Sofosbuvir, the scheme of treatment of patients with coexisting HIV and hepatitis can be used the same.

When side effects occur due to the combined use of the drug with "Interferon alfa", accompanied by serious disorders, Interferon refuses or reduces the previously established dosage. If Ribavirin is to blame for the development of serious side effects , its dose is also reduced or canceled by this medicine. Such decisions are made by the attending physician. Later, when the patient's condition is normal, you can try to resume taking medications.

Use of the medicinal product "Sofosbuvir"

When medicated with Sofosbuvir, the drug is administered in conjunction with a meal. The tablet is bitter, it can not be crushed and broken, you must swallow it whole.

If within two hours of taking the tablet, vomiting occurs, it is recommended to drink one more. In those cases where vomiting is observed after more than two hours, this action is not worth it.

If you miss a drug intake, when it has been no more than 18 hours, you have to take the missed dose, if more time passes, then the necessary dose of the drug is drunk at the usual time.

Discontinuation of therapy

If in the process of combined treatment there was a need for the cancellation of one of the drugs, they cancel the use of the drug "Sofosbuvir". The instruction shows that data on the treatment of adolescents and children, confirming the effectiveness of this method, are absent. When hepatitis is treated in patients who suffer from kidney failure (a mild or moderate form), there is no need for an individual dose selection. With a severe form of pathology, patients are prescribed a certain dose of the remedy necessary for their body.

Side effects of the drug "Sofosbuvir"

When treating "Sofosbuvir", "Interferon" and "Ribavirin", the same side effects appear, as in the treatment period only "Interferon" and "Ribavirin". In this case, their manifestation does not increase.

With combined treatment with the drug "Sofosbuvir" reviews show that its combination with "Ribavirin" often leads to the development of such conditions:

• Irritability, fatigue;
• headache;
• Increased bilirubin levels or decreased hemoglobin;
• nausea;
• Problems with sleep.

When the reception of the main drug is combined with the use of "Ribavirin" and "Interferon", it can often be noted:

• Myalgia, pain in the joints;
• Lack of sleep;
• Cough, shortness of breath;
• High level of bilirubin;
• Neutropenia, anemia, insufficient number of platelets, lymphocytes;
• Fever, chills;
• Increased irritability;
• Constant fatigue;
• Itching of the skin, rashes;
• Negative manifestations of the gastrointestinal tract;
• Headache, dizziness;
• Poor appetite.

When additionally applied "Ribavirin" except for the drug "Sofosbuvir", the instruction shows a slight probability of the development of such side effects:

• anemia;
• Disorders in the work of the digestive tract;
• Depressive conditions;
• Asthenia and fever;
• Convulsions;
• Problems with concentration;
• Myalgia;
• Pain in the back, in the joints;
• Rhinopharyngitis;
• Weakening of hair roots;
• Itching of the skin, increased dryness;
• cough;
• The appearance of dyspnea in the presence of exercise.

When therapy is combined with "Ribavirin" and "Interferon", the following undesirable reactions can be seen in some cases:

• Problems with vision and with concentration;
• Loss of skin moisture;
• reflux;
• Asthenia and discomfort in the chest, back;
• Weak hair roots;
• Depressive conditions;
• migraine;
• Convulsions;
• Anxiety and fear;
• constipation;
• Bad memory;
• Drying of the shell lining the oral cavity;
• Weight loss;
• Shortness of breath as a reaction of the body to the load.

To adverse reactions, which are most often found during the treatment with the drug "Sofosbuvir", the reviews include:

• Increased irritability;
• Constant fatigue;
• Decrease in hemoglobin concentration in the blood;
• Nausea;
• headache;
• Lack of sleep;
• High level of bilirubin.

Common undesirable effects are as follows:

• Disorders in the work of the digestive tract;
• Muscle cramps and pain in them;
• anemia;
• hair loss;
• Disturbance of the respiratory process;
• Depressive state;
• Attention deficit disorder;
• cough;
• Shortness of breath, which is the body's response to physical stress;
• fever;
• rhinitis;
• Lack of strength;
• Change in skin condition;
• Pain, felt in the back, joints.

The entire period of taking the drug "Sofosbuvir" must necessarily take place under the supervision of the attending physician. In no case can not self-prescribe this drug.

Drug Interactions

Complex therapy using Sophosbuvir means that reviews can be performed if the possible risks are exceeded. Experts do not advise to be treated simultaneously with this drug and "Boceprevir" or "Telaprevir". The same goes for the combination of the drug with medications, which are considered inducers of high-potency glucoproteins. To drugs with such properties belong to "Phenytoin", "Carbamacepin". Of these funds, it is possible to isolate St. John's wort and "Rifamycin". The possibility of combining certain medicines is established by the doctor.

special instructions

The course of treatment must be appointed by an experienced specialist. There is a risk of allergy, which is manifested by asthma, red eyes, itching, and swelling, itching mucous, rhinitis, rashes. Some patients may experience loss of consciousness, possibly anaphylactic shock. If you identify signs of an allergic reaction, you need the help of a doctor, if necessary - adjust the treatment regimen or cancel the use of the drug "Sofosbuvir" in general.

"Sofosbuvir", analogs of the drug are not used to treat patients under the age of eighteen, since the safety of such therapy has not been confirmed by studies.

It was noted that the incidence of adverse reactions is highest in patients over 35 years of age. The body of young people is better at taking medication.

Necessary drugs are selected by a doctor, taking into account many factors, including the genotype of the disease. During the treatment of hepatitis of the first genotype, a combination of "Ladipasvir" and "Sofosbuvir" preparations is allowed. In the second and third genotypes, the use of "Ribavirin" is possible, with the first or fourth genotypes - "Ribavirin" with "Interferon".

As studies have shown, "Sofosbuvir" most effectively treats the disease of 1-4 genotypes. In many cases, the effectiveness of therapy with the use of this drug was confirmed in the presence of a person not only of hepatitis, but also of the human immunodeficiency virus.

During therapy, the patient must introduce into his life some limitations. You can not perform tasks related to the need to show increased attention and respond quickly to what is happening.

For the body of pregnant women, the combination of Sofosbuvir + Ribavirin + Interferon is undesirable.

The cost of the drug, reviews, analogues of Sofosbuvira

It is worth knowing that when using Sophosbuvir, the price of such therapy will be very high. The drug is expensive, you can buy it for about 16-25 thousand euros. Although the drug is considered effective in combating started hepatitis C, it is possible that it does not help in all cases, because the body is different and differently responds to various means. Treatment requires special care, the choice of the necessary dose should be performed by a doctor, much depends on the expert's experience in the treatment of hepatitis "Sofosbuvir".

Sometimes you need to replace the drug "Sofosbuvir". The testimonies show that for the treatment of hepatitis C, which has not been eliminated at an acute stage, a doctor can be selected by a doctor who has a similar effect. Among the possible analogues - "Tsikloferon", "Ladipasvir", "Pegintron." The doctor can appoint "Neovir" or "Algeron". For the treatment can be used "Ferrovir", "Daklatasvir". There are also such substitutes as "Rebetol", "Ingaron". Therapy is possible with the "EU Reaferon", "Asunaprevir" or "Peginterferon". Often, doctors resort to the help of "Ribamidil", "Layfferon", "Altevir". A similar effect is achieved due to the reception of "Sovriada", "Pegasisa", "Ribavirin Medun". No less effective is "Roferon A". There are other medicines of similar action known - "Intron A", "Alfaron". Possible effective treatment of hepatitis, based on the use of "Realdirona" or "Moliksana."

"Sofosbuvir" (Egypt - the country-producer of funds) - the drug is expensive, so when you buy it, you need to take special care. It is important to pay attention to the reviews of people who have already bought this drug. Thus, it will be possible to learn about what side effects occur most often and whether or not the medicine is coping well with the task. Not only Egypt produces "Sofosbuvir". India also produces this drug.

The drug has undergone several clinical studies. As a result of six such procedures, the drug was approved, based on obtaining positive results. In the studies involved 1947 people with hepatitis C. For studies, people who had not previously treated their disease, and those patients whose body did not respond to previous therapy, were selected.

The effectiveness of the drug was proven in the treatment of a disease with a genotype from the first to the fourth. Good results were obtained as a result of the therapy of patients with both hepatitis and HIV. Approximately 50-90% of people participating in the research and suffering from hepatitis C had a stable virologic response. Many patients with chronic hepatitis and HIV infection due to the use of the drug received the same result. Virological sustained response was noted in 76-92% of people with co-infection.

Many people who suffer from chronic form of hepatitis C, leaving feedback, note that after passing a doctor-appointed course of treatment their condition returned to normal. Already after three months of combined therapy, the liver enzyme indications can be within normal limits, after about six months the disease can be forgotten, the virus does not appear in the blood. There are almost no mention of side effects, usually they are insignificant: fatigue, fatigue. Even if you are cured, you must be careful that the disease does not return.

Some people with the disease of the second genotype, the drug helps in just one month, the results of the analysis are good, the causative agent of hepatitis in the blood is not detected after therapy with the drug "Sofosbuvir". The price of the medicine is rather large, but, wanting to cure and forever forget about such an unpleasant illness as hepatitis C, people are at risk. Side effects are usually mild or moderate or none at all. And all the same, it is best to take the drug under the supervision of your doctor. There are no negative reviews, which means that if the doctor has prescribed the right treatment and drew attention to all the features of the patient's body, the state of his health, excluded the presence of contraindications, the result of therapy should be positive. It is important to understand that a competent specialist in the treatment of advanced hepatitis C is very important for obtaining good results and full recovery. Continuous monitoring of the doctor, adherence to all recommendations and maintaining a healthy lifestyle will certainly lead to better health. Even if you can not cure the disease completely, it will be possible to improve the indicators of the analysis, which necessarily will have a positive effect on well-being.