Spray nasal "Desrinitis": reviews of doctors, instructions for use and composition

"Desrinitis" is a synthetic glucocorticosteroid (SCS) of topical application. The active substance mometasone has an anti-allergic and anti-inflammatory effect. When the drug is used in doses that do not cause systemic effects, its anti-inflammatory local effect is manifested. Consider in this article about the drug "Desinit" reviews of doctors and consumers.

The drug inhibits the release of inflammatory mediators, increases the production of lipomodulin, an inhibitor of phospholipase A, and this leads to a decrease in the released arachidonic acid and inhibition of the synthesis of prostaglandins and cyclic endoperoxides. The drug causes prevention of neutrophil accumulation, reduction of inflammatory exudate and production of lymphokines, inhibition of migration of macrophages, reduction of granulation and infiltration processes, decrease in the formation of chemotaxis, that is, influence on the late reaction of allergy, the development of an instant allergic reaction stops.

This is confirmed by the drug "Desinit" reviews of doctors - specialists in their field. The composition of the agent includes mometasone furoate and auxiliary substances.

Pharmacokinetics

Intranasal administration reduces the systemic bioavailability of mometasone fuorate to less than 1%. An active substance that can enter the digestive tract is absorbed in small amounts and biotransformed actively after the first passage through the liver. About the drug "Desinit" reviews of doctors are mostly positive.

Indicated for use with:

• Treatment of all-the-year-round and seasonal allergic rhinitis of children from 2 years old and older and adults;
• Acute sinusitis, exacerbation of chronic sinusitis in children aged 12 years and older, as well as adults (including the elderly) as an auxiliary means of antibiotic treatment;
• Treatment of adenoids in children or polyposis of the nose of adults;
• Prevention of allergic seasonal rhinitis in severe and moderate conditions of children aged 12 years and older, as well as adults. Conducted recommended four weeks before the start of the dusting season.

Form of issue

Dosage nasal spray. One bottle contains 140 doses. In the directory of the form of this drug in the form of drops did not exist during the publication of the drug. "Desrinitis" is suitable for children. The doctors' testimonies confirm this.

Method of use and instructions for use

The drug is administered intranasally. The spray contained in the vial is injected into the nose with a special dosing device.

Before starting the spray application, you need to do 10 test presses on the dosing device. After calibration, the drug delivery rate is set, each depression releases a suspension of 100 mg, which contains 50 μg of mometasone. Before applying the drug after more than 14-day break, the calibration will need to be repeated. Each application should be accompanied by a preliminary shaking of the vial.

Side effects

About the preparation "Desinit" doctors' reviews indicate the following possible side effects:

• glaucoma;
• Hypersensitivity reactions, including dyspnea and bronchospasm;
• anaphylaxis;
• Headache in children and adults;
• Angioedema;
• nose bleed;
• Burning of the nasal cavity;
• Children may experience growth retardation, psychomotor hyperactivity, sleep disorders, anxiety, aggressive behavior, depression;
• pharyngitis;
• Perforation of the nasal septum ;
• Sensation of irritation of the mucosa in the nasal cavity;
• Sensation of irritation of the pharyngeal mucosa;
• Upper respiratory tract infections;
• Sneezing;
• A taste disorder;
• Impaired sense of smell;
• cataract;
• Increased intraocular pressure;
• Ulceration of the mucosa in the nasal cavity.

Contraindications

The drug "Desinitis" (doctors' reviews confirm this) are contraindicated when:

• Hypersensitivity to mometasone or any component of the drug;
• Recent surgery or nasal trauma to wound healing, since SCS acts in an inhibitory manner on healing processes;
• In childhood (with polyposis of the nasal cavity to 18 years, with exacerbations of chronic sinusitis or acute form up to 12 years, with year-round and seasonal allergic rhinitis up to 2 years).

Use of the drug during pregnancy and breastfeeding

Specifically, no studies of the safe use of "Desrinitis" in pregnancy and lactation have been conducted. This drug should be given to breastfeeding women and pregnant women only if the benefits to the mother's health exceed the potential risks to the child or fetus. Newborns, whose mothers used SCS during pregnancy, need a special examination to identify possible hypofunction of the adrenal glands. This is confirmed by the "Desrinitis" medication of immunologists.

Use of the drug for children

The use of "Desinitis" is contraindicated in children with polyposis of the nasal cavity up to 18 years; With exacerbation of chronic sinusitis or acute form up to 12 years; With year-round and seasonal allergic rhinitis up to 2 years. Often used "Desinitis" in adenoids in children. The doctors' comments on this score are positive.

Instructions for use

Signs of atrophy of the nasal mucosa after application of the drug during the year (12 months) were not noted. A study of biopsy specimens of the nasal mucosa revealed the influence of mometasone on the tendency to normalize the histological picture. Long-term use of the drug, like any long-term treatment, involves a periodic examination of the nasal mucosa by an otorhinolaryngologist.

With tuberculosis of the respiratory tract (latent or active); Bacterial, systemic viral (including herpes, affecting the eyes or Herpes simplex) or fungal infection; Long-term treatment through GCS; Presence of untreated local infection of the nasal mucosa, as well as breastfeeding and pregnancy, the drug should be prescribed with great care.

Treatment with "Desinitis" is recommended to stop and begin to conduct special therapy when developing a fungal local infection of the pharynx or nose.

The irritation of the pharyngeal mucosa and the nasal cavity, which persists for a very long period of time, can be considered an indication to refuse the use of the drug. It can also be noted that suppression of the hypothalamic-pituitary-adrenal system after prolonged use of the drug has not been identified. This is indicated by the reviews about the drug "Desinit".

Special attention is required by patients who received long-term treatment with glucocorticosteroids, which are switched to treatment with mometasone. If you cancel the SCS of a systemic action, then with some probability it can be said that this will cause adrenal insufficiency, the treatment of which will require appropriate measures.

In some patients with the transition to treatment with mometasone after GCS, symptoms of cancellation of glucocorticosteroids of systemic use may occur. These include depression, a feeling of fatigue, pain in the muscles and / or joints. Patients should be specifically convinced that treatment with the drug "Desinitis" is appropriate, despite the reduction in the severity of symptoms of nasal mucosa. Masked (but already existing in the patient) treatment of glucocorticosteroids of systemic action such allergic diseases as eczema and conjunctivitis can be detected by the transition from GCS to local.

In the treatment of polyps unilateral; Polyps that are associated with cystic fibrosis, and polyps that completely cover the nasal cavity, the safety and effectiveness of the application of "Desrinitis" has not been studied. Bleeding and unilateral polyps, having an irregular shape, should be investigated additionally.

Patients receiving therapy with SCS acquire reduced immune reactivity, and therefore should be warned about the increased risk of infection through contact with sick measles, chickenpox and some other infectious diseases, and the need for consultation with a specialist if contact with the patient still Took place.

Long-term use of GCS nasal in large doses can be a catalyst for the development of side effects. However, these effects can occur with much less probability than when systemic GCS is used, and differ in individual patients. A potential systemic effect is Cushing's syndrome, characterized by suppression of adrenal function, glaucoma, cataracts, growth retardation in adolescents and children, and sometimes a number of behavioral and psychological effects, including anxiety, sleep disorders, aggression or depression, psychomotor hyperactivity.

As for the drug interaction of various drugs with mometasone, no studies have been carried out on this.

Spray nasal «Teva Desrinitis»: reviews of buyers and doctors

Reviews about the drug are mostly positive. Good for allergic rhinitis. It is normally tolerated, rarely gives side effects. To small children helps with adenoids, relieves inflammation. The main thing is to follow the instructions for use.