Health, Preparations
Preparation "Pregnil": reviews, instruction
Many women today suffer from infertility. Thanks to modern medical products, you can solve the problem and feel the joy of motherhood. One of the popular and proven drugs can be called "Pregnil". Almost all happy patients leave their comments.
Formula and composition of the preparation
It is a recombinant human chorionic gonadotropin. The drug is administered subcutaneously and intramuscularly. The drug's leofilisate is white. To him in the kit is a bottle of solvent. It is transparent and colorless. The main substance of the drug "Pregnil" is the human chorionic gonadotropin. Auxiliary components are magnesium hydrophosphate, carmelose sodium, mannitol, sodium dihydrogen phosphate.
pharmachologic effect
The medicine "Pregnil" contains human chorionic gonadotropin. It has a high degree of similarity with the action of luteinizing hormone. This substance is indispensable for normal growth and maturation of male and female gametes. Also, LG is needed to create sex hormones. It is equally useful to both women and members of the stronger sex. To representatives of the weaker sex, the drug "Pregnil" replaces the formation in the middle of the cycle of endogenous luteinizing hormone to help complete the phase of the formation of follicles that are responsible for ovulation.
For men, the medicine "Pregnil" stimulates the production of Leydig cells. Thanks to timely treatment, it is possible to normalize the level of testosterone in the blood from the stronger sex.
Pharmacokinetics of the drug
The highest peak in blood plasma chorionic gonadotropin after injection reaches eight hours in men and 20 hours in women. There is a big difference between the absorption of the substance after the injection in different sexes. In women, the rate of hormone concentration in the body is delayed. This reaction is most related to the increased thickness of adipose tissue in the body.
Dosage
After diluting the dry substance with a solvent, it is necessary to inject the injection intramuscularly or subcutaneously. To create ovulation with infertility in the absence of it or disturb the maturation of the follicles, a woman is administered from 5000 to 10 000 IU of the drug "Pregnil".
To complete the treatment with follicle-stimulating drugs, it is enough to make one injection of "Pregnil". The doctors' comments show that the therapeutic effect occurs within a month. The drug is administered before ovarian puncture while passing the hyperstimulation control program. To maintain the phase of the formation of the yellow body, it is necessary to inject in a dosage of 1000 to 3000 IU. The injections are made on the third, sixth and ninth day of artificially induced ovulation.
In men with a low content of testosterone in the body, injections are given at a dose of 1000 to 2000 IU twice a week. When developing infertility, you need to add additional drugs to the preparation of "Pregnil". For example, the substance "Phyllithropine". It must also be stabbed twice a week. The course can last up to 3 months. In this case, it is necessary to expect an increase in spermatogenesis. When treating with the drug "Pregnil" you need to give up substitution therapy with testosterone.
Dosage of the drug in childhood
In boys with a delay in puberty, "Pregnil" is administered at a dose of 1500 IU twice a week for six months. In children under 2 years of age, the drug is administered at a dosage of 250 IU twice a week for 6 weeks. Up to 6 years, the dosage is 500-1000 IU. The course of the decay can be quite long. After 6 years, the dose of the drug reaches 1500 IU.
With insufficient therapeutic effect, treatment is recommended to be repeated.
Side effects
In very rare cases, a generalized rash or fever may occur. There is also a local reaction at the injection site. It is manifested by swelling, tenderness and itching. Women do not often develop thromboembolism after passing the course with the drug "Pregnil 5000". The reviews show that the side effects are temporary and pass quickly.
In men and adolescents, in the treatment of large doses of the drug "Pregnil", water and sodium can be delayed in the body. This occurs as a result of an excess of adrogen. There may be an increase in mammary glands.
As it is possible to understand, there are many side effects of the preparation "Pregnil". Feedback from specialists shows that the presented symptoms are not dangerous to health. However, they should be reported to the attending physician.
Contraindications to drug treatment
Some patients may develop an increased sensitivity to the main substance of the drug "Pregnil" (gonadotropin) and its auxiliary components. Do not prescribe a remedy for suspected or having tumors in women of different etiologies.
Reviews about the medicine
The drug gives an excellent effect in the violation of ovarian maturation, the absence of ovulation in infertility. In men and adolescents with a small testosterone content, the medicine also brings an excellent therapeutic result.
Negative reviews of the medication are also available. They are most often connected with the wrong drug intake.
Usually the drug is used to treat infertility in women. You can hear more often good about the preparation "Pregnil 5000" reviews. Who became pregnant, he knows how important is timely therapy.
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