"Ostererepair": instructions for use, reviews, manufacturer, analogs

Reducing the level of mineral substances in bone tissue is the cause of a huge amount of damage to the bone and joint apparatus in people of different age groups. Quite often bone density is reduced due to increased bone destruction - the so-called bone resorption. Normalization of physiological processes between destruction and creation of bone tissue is the main goal of treating diseases of this kind. One of the medicines used to treat osteoporosis is "Ostererepair". Let's analyze what is said about the drug "Ostererepar" instruction for use, reviews of doctors and patients.

Pharmacological characteristics

The active substance of the drug "Ostererepair" is alendronic acid, which is presented as a sodium salt - sodium alendronate. The very mechanism of action of this substance is not fully understood, but it is known that the end point of the action of sodium alendronate is the restoration of a positive balance between destruction and restoration of bone tissue. Partially this process is realized due to oppression of osteoclasts - specialized cells of bone tissue, responsible for its destruction.

In addition, it is known that a decrease in the amount of plasma calcium causes its accumulation in the bone tissue against the background of taking the drug "Ostererepas". The instructions for use say that this helps to strengthen the bone structure and reduce the risk of fractures.

Pharmacokinetic features

Despite the fact that sodium alendronate is readily soluble in water and aqueous solutions, the absorption of the drug from the intestinal lumen can not be called good - the absorption is only about 25%. It is known that "Ostererepair" quite well binds to plasma proteins (the degree of binding reaches 70-75%), is not metabolized in the body.

Indications for the use of the drug "Ostererepair"

The instructions for use say that the drug is indicated for deforming bone disorders, which are called osteoporosis (including postmenopausal osteoporosis in women). Successfully, sodium alendronate is used to treat elevated plasma calcium levels in patients with malignant processes.

Contraindications

Official to the preparation "Osterepar" instruction contains a complete list of contraindications to the prescription of the drug. So, "Osterepar" is contraindicated for use in children, since the effectiveness of the drug and the safety of its use have not been finally determined.

Alendronate sodium is not prescribed for the development of lactation, breastfeeding and pregnancy. Also, the drug is contraindicated with a decreased level of plasma calcium, rickets and vitamin D deficiency. With caution, the drug should be prescribed in patients with insufficient renal excretory function.

Side effects

Before the introduction to the clinical practice of sodium alendronate passed a double-blind placebo-controlled study. According to the results of these studies, the incidence of adverse reactions among patients taking alendronate sodium was slightly lower than the incidence of adverse reactions in patients taking placebo.

Among the adverse reactions caused by the drug "Ostererepair", patients noted disorders of the gastrointestinal tract (dyspepsia, abdominal pain, stool disorders with a tendency to constipation), as well as the central nervous system (headache). There are other side effects associated with the use of the drug "Ostererepair". Instructions for use indicate very rare allergic reactions in the form of rash or itchy skin.

special instructions

Taking "Ostererepair", tablets should be washed down with ordinary drinking water, since other drinks (mineral water, milk, fruit juices) can influence the bioavailability of the drug and slow its absorption. In view of the fact that alendronate sodium is capable of irritating the upper sections of the gastrointestinal tract, the tablets should be washed down with a large volume of water (a full glass). In the horizontal position, there is an increased risk of esophageal damage when taking the drug "Osterepar". Instruction for use says that it is not necessary to lie down for at least half an hour after taking the medication, and also take the medicine before going to bed.

With caution, the drug is prescribed for patients who have dental diseases, including tumorigenesis. When appointing "Osterepara" it is recommended to undergo a full dental examination and conduct a full sanation of the oral cavity. During the reception, dental procedures should be avoided.

With prolonged therapy (more than one and a half years) with drugs from the group of bisphosphonates, there may be fractures of the femur in the proximal part. In case of a fracture of the patient, it is recommended to send for examination of the second femur to reduce the likelihood of a repeated fracture. In addition, the therapy "Osereparem" is terminated before the time of assessment of the benefits and risks of treatment.

Of particular note deserves the appointment of "Osterepara" in patients taking glucocorticosteroids. These drugs can reduce absorption and, accordingly, the intake of calcium and vitamin D in the body. In such patients, hypocalcemia can be asymptomatic and manifest in severe form with a hereditary predisposition. In order to prevent this complication and timely diagnosis of hypocalcemia, it is recommended to provide adequate intake of calcium and vitamin D.

The drug is not assigned to patients with rare and genetically determined diseases associated with intolerance to lactose.

The drug does not affect the reaction rate and the ability to control the mechanisms. However, it must be remembered that the complications and side reactions that occur after taking "Ostererepair" can affect these processes.

Drug Interactions

"Osterepar" is not recommended for joint use with aspirin, as acetylsalicylic acid increases the side effects of alendronate sodium (especially its effect on the intestinal tract). However, "Ostererepair" is well tolerated in patients additionally receiving anti-inflammatory therapy with non-steroid drugs. Despite this fact, one should refrain from the combined use of these medicines, since non-steroidal anti-inflammatory drugs themselves are capable of causing significant side effects.

The appointment of alendronic acid to women who additionally take estrogens in combination with progesterones promoted a more pronounced increase in bone mass with a significant decrease in bone resorption.

Thyroid diuretic therapy in combination with the appointment of alendronic acid leads to a decrease in calcium loss by the body and reduces the effect of "Ostererepar".

Poisoning and drug overdose

When poisoning with alendronic acid, there are disorders of the intestine, manifested as vomiting, heartburn, esophagitis and ulceration in the lumen of the intestine. On the part of the bone system and the blood system, hypocalcemia and hypophosphatemia may occur.

The treatment of poisoning and overdose is aimed at binding the drug in the lumen of the intestine and its inactivation. To do this, you can use milk, calcium-based antacids, astringents. Self-induced vomiting can not be caused, since the drug can cause irritation and burn of the esophagus. To wash the stomach should use a probe. Therapy is symptomatic, and also aimed at stabilizing the level of calcium in the blood plasma.

Reviews of doctors and patients

About the drug "Ostereparar" reviews are different, but more positive. On the part of patients taking the drug, the indignation is due to the irritant effect of the drug on the intestinal mucosa. From the point of view of doctors, the drug "Ostererepair", analogues of this medicine containing alendronate of sodium, are effective in the treatment of osteoporosis of various genesis, as well as diseases of the musculoskeletal system.

Drug analogues

In the pharmaceutical market, there are a sufficient number of analogues of the preparation containing alendronate sodium as an active substance. "Alendronate", "Alendronovaya acid", "Alental", "Stringos", Tevanat ». All these, as well as many other medicines, are analogues of the drug "Ostererepair".

Instructions for use of analogues of the drug does not indicate, however, if the composition contains alendronic acid, the drug can be used uniquely for the treatment of osteoporosis.

Conclusion

Osteoporosis is an insidious disease, and its therapy is complex and time-consuming. As they say about the drug "Ostererepar" instructions for use, the manufacturer, patients and attending physicians, the use of the agent has a beneficial effect on the bone system, normalizing the phosphorus-calcium metabolism and reducing the resorption of bone tissue.

However, at the time of taking the drug, in order to obtain the maximum effect, it is necessary to adhere to several simple rules described in the instructions for use, and constant communication with your doctor will avoid undesirable effects of the drug. During treatment, do not neglect the appointment of a specialist, as they are the key to successful therapy and speedy recovery.