"Ortanol": what helps, instructions for use, feedback

What is the medication "Ortanol"? What helps the medicine? The answers to these questions will be found below. In addition, we will present the price of the drug, its contraindications, analogs and form of release.

Packaging of the medicinal product, its composition, description, form

The drug "Ortanol" is made in the form of hard capsules the size of No. 1 or No. 2. This tool is white, and also the inscription "OME 20" or "OME 40" (depending on the dosage). The contents of the medicinal capsules are yellow granules.

What does Ortanol mean? Reviews indicate that the main substance of the drug in question is omeprazole. It also has such auxiliary components as croscarmellose sodium, low-substituted giprolose, anhydrous lactose, microcrystalline cellulose, hypromellose phthalate, povidone, polysorbate 80, talc and dibutyl sebacate.

The capsule shell includes: propylene glycol, hypromellose, butanol, carrageenan, anhydrous anhydrous, shellac, potassium chloride, isopropanol anhydrous, titanium dioxide, ink for inscription and water.

In sale, the medication "Ortanol" (capsules) comes in blisters, packaged in packs of cardboard.

Pharmacological action

What is "Ortanol" (what helps this medicine, you will learn below)? According to the instructions, this preparation is an inhibitor of a proton pump. It reduces acid production, that is, it slows down the activity of K + -H + -ATPase in the stomach, or rather in its parietal cells. It also blocks the last stage of acid secretion by hydrochloric acid.

The drug "Ortanol", the price of which is listed below, is a prodrug. This agent is activated in the acidic environment of tubules (secretory) parietal cells. In addition, it reduces stimulated and basal secretion, regardless of the nature of the stimulus.

The antisecretory properties of this medication appear within the first 60 minutes (maximum after 2 hours). Inhibition of 50% of maximum secretion continues throughout the day.

A single dose of the drug provides effective and rapid suppression of night and daytime gastric secretion. Its maximum reaches on the 4th day of therapy and disappears after three days after the end of treatment.

Kinetic properties of medication

After taking the drug "Ortanol", it reaches a high absorption. The peak concentration of omeprazole in the blood is observed after 0.5-3 hours. Absolute bioavailability of the drug is 30-40%, and the connection of the drug with plasma proteins is 95%.

Metabolism omeprazole is carried out in the liver with the formation of six pharmacologically inactive derivatives.

The half-life of the drug is 0.5-1 hours. It is derived as a derivative by means of the kidneys (70-76%) and together with bile (18-24%).

In people with chronic liver diseases, the bioavailability of the drug is significantly increased, and the half-life from plasma reaches 3 hours.

In patients with chronic kidney disease, excretion slows down. This happens in proportion to the decrease in QC.

Medication "Ortanol": from what helps?

This drug is indicated for use in the following diseases:

• Reflux-esophagitis;
• Diseases of the gastrointestinal organs ulcerative (including for the prevention of relapses);
• States of hypersecretory (stress ulcers of the gastrointestinal tract, Zollinger-Ellison syndrome, systemic mastocytosis, polyendocrine adenomatosis);
• Eradication Helikobakter Pilori in infected patients with gastrointestinal ulcer (in combination therapy);

• Treatment and prevention of damage to the mucosa of the gastrointestinal tract, which are caused by the intake of NSAIDs (mucosal erosion, dyspepsia, peptic ulcer).

Prohibitions to use the medicine

What kind of contraindications does the medication "Ortanol" have (what helps this remedy, we have told above)? According to the instructions, the medicine in question can not be used when:

• Lactation;
• In childhood;
• Hypersensitivity to drug substances.

With special care, this drug is prescribed for renal and hepatic insufficiency.

Orthanol drug: instructions

This drug is prescribed only by mouth. It is taken immediately before meals (usually in the morning, before breakfast).

The capsule with the medicinal substance is swallowed in its entirety, washed down with water. In the event that the patient can not use the whole medicine, its contents can be dissolved in a small amount of not very acidic liquid.

The dosage of this drug depends on the indications.

With duodenal ulcer 12 mg of medication is prescribed for 20 mg once a day for two weeks. In the event that, after the first course, complete scarring does not occur, a second two-week therapy is prescribed.

With a peptic ulcer resistant to treatment, this drug is recommended to take in a dosage of 40 mg once a day. The course of therapy with this drug can be extended to four weeks.

Capsules "Ortanol", the indications of which were listed above, with gastric ulceration take 20 mg once a day for four weeks. If, after the passed course, scarring does not occur, then a repeated four-week therapy is prescribed. With a gastric ulcer resistant to treatment, the drug is recommended to take a dose of 40 mg once a day (course up to eight weeks).

Helicobacter pylori eradication is carried out as a part of combined therapy. In this case, the medication is prescribed 20 mg twice daily before meals (for two weeks) in combination with antibacterial agents.

When reflux-esophagitis drug is recommended to use in an amount of 20 mg (once) for four weeks. If this medication does not contribute to a complete cure, the patient is given a second course (four weeks). In severe form of reflux esophagitis, this medication is prolonged to eight weeks.

In hypersecretory states, the medication prescribed for heartburn is appointed individually. The recommended initial dosage for adults is 60 mg (once), and the maximum dosage is 120 mg.

When prescribing a drug over 80 mg per day, it is divided into several receptions.

If lesions of the mucous organs of the digestive tract, which are caused by the intake of NSAIDs, and also for the prophylaxis of the capsule, "Ortanol" is recommended to use at a dose of 20 mg every day, before breakfast (throughout the course of treatment with NSAIDs).

For the elderly and people with severe liver disease, the greatest daily dose of the drug is 20 mg.

For patients with impaired renal function, dosage adjustment is not required.

Occasional phenomena

What reactions of an undesirable character are caused by the medication Ortanol? The reviews indicate the following side effects:

• Headache, impaired vision, dizziness, exudative erythema multiforme, paresthesia;
• Drowsiness, nausea, a violation of taste, diarrhea, insomnia, flatulence;
• Excitation, dry mouth, depression, stomatitis, reversible confusion;
• Encephalopathy, gynecomastia, hepatitis, peripheral edema, vomiting, photosensitivity;
• Abdominal pain, thrombocytopenia, constipation, pancytopenia, increased activity of alkaline phosphatase and liver transaminase;
• Cutaneous itching, disruption of the liver, muscle weakness, the formation of gastric cysts glandular;
• Alopecia, eosinophilia, increased sweating, bronchospasm, agranulocytosis, angioedema;
• Leukopenia, myalgia, fever, arthralgia, anaphylactoid reactions, urticaria, interstitial nephritis.

Adverse events that are observed with the use of the agent in question are mildly expressed and transient.

Cases of overdose

When taking the medication for heartburn, the patient may experience the following symptoms: headache, dry mouth, tachycardia, drowsiness, nausea, visual impairment, vomiting, confusion, increased sweating.

With such conditions, symptomatic therapy is performed.

Drug Interactions

With simultaneous admission with omeprazole, the elimination half-life increases and the concentration of Diazepam, Warfarin, and Phenytoin increases, as well as other drugs that are metabolized in the liver with the participation of the CYP2C19 isoenzyme.

The absorption of drugs whose bioavailability is determined by the acidity of gastric juice (for example, Itraconazole, Ketoconazole, ampicillin esters, Cyanocobalamin and iron salts) may be impaired.

The bioavailability of digoxin in co-administration with omeprazole is increased by 10%.

This drug enhances the inhibitory effect on the hematopoiesis system of other drugs.

Clinically significant interaction of the drug with antacid medicines, caffeine, "Theophylline", "Quinidine", "Propranolol", ethanol, lidocaine and "Metoprolol" is not established.

Special Recommendations

Before starting treatment with omeprazole, the presence of a malignant process should be excluded. This is due to the fact that therapy with this drug can mask symptoms and delay the setting of a true diagnosis.

Currently, there is no data on the impact of the funds in question on a person's ability to manage machinery and drive vehicles.

Cost and analogy

How much is an antiulcer medication like Ortanol? The price of this medicine is about 100-115 rubles. For most consumers, this cost is quite acceptable.

What can replace the drug "Ortanol"? Analogues of this drug are presented in the form of "Omez", "Loseprazol", "Gasek", "Omelika", "Omeprazole."

Reviews

Reviews about capsules "Ortanol" are more positive. Patients claim that this drug is an effective antiulcer. It quickly eliminates heartburn, as well as a feeling of heaviness and burning in the stomach.

Experts argue that the medication in question positively affects the course of diseases of the digestive tract only if it was prescribed by a gastroenterologist. Doctors say that it is forbidden to take this medication on their own, as it has a very strong effect.

Also, the positive side of this drug is its availability and cheapness.