"Nebilong": instructions for use. "Nebilong": reviews and analogues

"Nebilong" is an effective drug designed to treat diseases associated with cardiac dysfunction. Improvements can be achieved after using it for one month. After the application of "Nebilong", the pulse and blood pressure normalize, vascular relaxation is achieved, and a sufficient amount of oxygen enters the myocardium. In almost all cases, a positive result of therapy persists for a long time.

Composition, form of release

The drug is available in tablets. One tablet can contain 2.5, 5 or 10 mg of the active ingredient. The drug is made on the basis of nebivolol hydrochloride. Of the excipients in the composition there are povidone, lactose, magnesium stearate. The composition is supplemented with talc, microcrystalline cellulose, sodium dioctyl sulfate, colloidal silicon dioxide, croscarmellose sodium, beta-cyclodextrin.

pharmachologic effect

"Nebilong" instructions for use displays as a tool that has in its composition two enantiomers (L- and D-nebivolol). D-Nebivolol is a highly selective, competitive blocker of β1-adrenergic receptors, L-nebivolol gently affects the vessels, expands them, which occurs as a result of the process taking place in the vascular endothelium (modulation of vasodilating factor release).

Nebivolol helps reduce blood pressure and heart rate, the result is not only in a state of rest, but also under stress. After taking the drug, the OPSS and the end-diastolic pressure of the left ventricle decrease, and a positive effect on one of the functions performed by the heart, a diastolic one, is observed. Due to the use of "Nebilong", the ejection fraction increases, in people with ischemic heart disease there is an antianginal effect.

The hypotensive action performed by Nebilong tablets is explained by the decrease in activity in the renin-angiotensin system. Antiarrhythmic action is achieved by reducing AV-conduction and suppressing the pathological automatism of the heart. A stable antihypertensive effect occurs after 7-14 days of treatment, often in a month. Stable result from the taking of tablets is noted after one to two months of treatment.

Pharmacokinetics

The drug taken internally, is absorbed well, this process is equally effective, regardless of food intake. Metabolism is carried out in the liver and concludes with the formation of active hydroxymetabolites. On average, the bioavailability after internal use of the drug by a person with a fast metabolism is 12%, with a slow metabolism this rate is much higher. Since the metabolism in patients can proceed at different rates, the "Nebilong" instruction recommends the appointment taking into account the individual characteristics of the patient's body. With a slow metabolism, low doses of the drug are used. In persons with rapid metabolism, half-elimination occurs in about 10 hours, in patients whose metabolism is slower, the half-life is increased 3-5 times. After seven days of therapy, about 38% of the drug taken is excreted by the kidneys, approximately 48% of the "Nebilong" is present in the feces. In the urine there is a small amount of the drug in the unchanged form - up to 0.5%.

Indications

The instruction on the use of "Nebilong" allows using with hypertension, for the implementation of preventive measures in patients with ischemic heart disease (attacks of angina pectoris) and for the implementation of complex therapy for chronic heart failure.

Treatment with the drug "Nebilong"

Hypertension

Adult patients are prescribed 5 mg of Nebilong, which corresponds to one tablet of the drug and is a daily dose. It is recommended to take the medicine daily, at the same time. A small effect is noticeable after one to two weeks of therapy, the most pronounced it is in a month, during which treatment was performed. Tablets are suitable for both monotherapy and for treatment based on the integrated use of drugs that also have antihypertensive effects. To people who take Nebelong AM, the instruction recommends using hydrochlorothiazide for 12.5-25 mg in order to obtain an additional effect. This combination treatment allows you to strengthen the action of Nebilong, but you can do this only after receiving the advice of a doctor.

Heart failure of chronic form

First, a small dose of the drug is used, which the doctor gradually increases, taking into account the characteristics of the patient's body. For the treatment of acute disease, "Nebilong" is not suitable, in such cases, other drugs are used. Usually, first prescribe 1.25 mg of medication for a single daily intake, after 1-2 weeks the dose may be increased to 5 mg, later - up to 10 mg. The daily dose can not exceed 10 mg of the drug "Nebilong". The instructions for use show that at the initial stage of the therapy the patient is left under observation for two hours after taking the pill, also at each increase in the dose of the drug. Increased dose can be reduced again if there is such a need.

If symptoms of heart failure are more pronounced, or the patient has been found to be intolerant to the components of the drug, reduce the dose of the drug or cancel it. Usually heart failure of a chronic form of "Nebilong" is treated quickly. With therapy aimed at eliminating such conditions, drug withdrawal is slow, it is impossible to perform this action dramatically, as the problem may worsen. If you cancel the medication every week, you can reduce its dose by half. For the reception of Niebelong AM tablets, the instructions for use provide for certain restrictions.

Restrictions:

• Renal insufficiency. First for therapy use 2.5 mg of the drug per day, later the dose can be increased, but it should not exceed 5 mg.
• Elderly age. The initial dose can not exceed 2.5 mg, if necessary, it is increased to 5 mg. After 65 years, a regular check of kidney activity is required (once every four to five months).
• Pregnancy. A newborn can develop some pathologies, such as respiratory paralysis, hypoglycemia, hypotension, bradycardia, so it is very rarely prescribed for a pregnant woman. If a pregnant woman uses Nebilong, his cancellation is required 48-72 hours prior to delivery. If this is not possible, the newborn should be observed for 48-72 hours.

Contraindications

"Nebilong N" instructions for use prohibit the use in the following cases:

• Age is less than 18 years;
• Increased sensitivity to the components of the drug;
• Bronchospasm, asthma;
• Pheochromocytoma, whose treatment was not previously performed;
• Metabolic acidosis;
• Severe liver disease, hepatic impairment;
• Hypotension in persons whose systolic pressure is 90 or less mm Hg. P.
• AV-blockade (degree I, III), a bradycardia, which is accompanied by a heart rate corresponding to 60 beats. in a minute;
• The period of gestation, breastfeeding;
• Heart failure of acute form;
• Problems with peripheral circulation, which have a pronounced effect;
• Cardiogenic shock, conditions in which it is necessary to use isotropic drugs;
• Syndrome, accompanied by weakness of the sinus node.

Care is needed when prescribing a drug to patients with such conditions:

• diabetes;
• Psoriasis (anamnesis);
• Angina of Prinzmetal.

Adverse events

When treatment with Nebilong means an instruction for use, the reviews indicate the likelihood of some side effects that appear in the work of the cardiovascular, digestive and nervous systems. Among other disorders - bronchospasm, reactions that affect the skin condition.

special instructions

"Nebilong" can cause an increase in sensitivity to allergens, which threatens the development of a pronounced anaphylactic reaction.

Treatment with the drug does not affect the level of glucose in the body in the presence of diabetes, but patients of this group should use the medicine with caution. As with diabetes, and with hyperthyroidism, the drug can mask symptoms of tachycardia, which are more pronounced due to the abrupt withdrawal of tablets.

If patients with problems in the respiratory system use "Nebilong", the instruction for use reports the probability of increasing the constriction of the airways in COPD. The possibility of combining the drug with other drugs should be checked with your doctor.

"Nebilong" has an impact on the ability to drive a vehicle, can lead to fatigue and dizziness.

Analogues

There is the possibility of replacing the drug, when the use of the drug "Nebilong" does not allow the instruction for use. Analogues of the drug include "Nebilet", "Binelol". Substitutes also include Nebikor and Nebivator.

Reviews

As the reviews show, the drug is effective when used correctly. It is very important to use the medicine correctly and follow all the doctor's recommendations. A medication prescribed taking into account contraindications and peculiarities of the patient's body leads to a positive effect. To treatment did not lead to the development of side effects, it is necessary to constantly monitor the patient's condition.