Medication "Metformin". Reviews. annotation

The drug "Metformin" refers to the oral hypoglycemic agents of the biguanide group. When used by patients with diabetes, the drug lowers the level of glucose in the blood by suppressing gluconeogenesis in the liver, as well as reducing its absorption from the digestive system. Thanks to an increase in the sensitivity of insulin to tissues, its (glucose) utilization is increased. Medication "Metformin" (reviews of specialists testify to this) has an effect on lipid metabolism. The drug helps reduce the content of triglycerides, LDL, cholesterol in the serum. The drug also reduces (stabilizes) the increased body weight. When penetrating the inside, the absorption of the agent is of the order of 48-52%. With simultaneous consumption of food absorption decreases. The maximum concentration reaches 2-3 hours later. The drug is slightly associated with plasma proteins, is metabolized to a weak degree.

Means of Metformin. Application

The medication is prescribed for the second type of diabetes (sugar) in adults (especially those suffering from obesity) in the absence of effect from physical exertion, diet therapy. Medication "Metformin" (doctor's testimonies testify to this) can be used as a monotherapy or as part of a complex of hypoglycemic oral medications or with insulin. The drug is also prescribed for children from the age of ten with type 2 diabetes mellitus as a monotherapy or as part of a complex treatment.

Contraindications

Medication "Metformin" (reviews of doctors warn about this) should not be taken with diabetic coma, precoma, ketoacidosis, hypersensitivity. Contraindications include conditions of an acute nature that develop with the likelihood of the onset of renal dysfunction. The drug is not recommended in the state of hypoxia, with dehydration, bronchopulmonary pathologies, infective lesions in the kidneys, sepsis, shock, liver failure, acute alcohol poisoning, lactic acidosis, including history. The drug is not recommended for clinically expressed symptoms of chronic or acute pathologies that can provoke tissue hypoxia. Such conditions include acute myocardial infarction, respiratory, heart failure and others. Do not prescribe a drug before the age of ten, with a hypocaloric diet. Caution is shown in the treatment of elderly (over 60 years) patients whose activities are associated with physical stress.

Side effects

Medication "Metformin" (expert reviews indicate this) can lead to worsening of appetite, vomiting, nausea, taste disorders, diarrhea, rash, erythema, other allergic skin manifestations. To improve gastrointestinal tolerance, it is recommended to slowly increase the dose. On the basis of therapy there is soreness in the abdomen, hepatitis, violations in the activity of the liver. As a rule, when the medicine is canceled, these negative consequences are passed. Against the backdrop of prolonged use, hypovitaminosis B12, folic acid may develop.