"Lomflow": instructions for use, price, analogues

Why can a medication such as Lomflox be prescribed? Instructions for use, contraindications and indications for taking this medication will be detailed in this article. In addition, from it you will learn about the form in which this drug is produced, what substances are included in its composition, how much it costs and whether it has analogues.

Packaging of the drug, its form, description and composition

In what form is produced such a drug as Lomflox? Instruction for use informs you that this medication goes on sale only in the form of film-coated (film) oblong tablets (400 mg) of light brown color.

The active ingredient of this agent is lomefloxacin (used in the form of hydrochloride). As for the additional components, they include lactose, purified talc, starch, crospovidone, polyvinylpyrrolidone, sodium lauryl sulfate, propylene glycol, magnesium stearate, sodium starch glycolate and colloidal silicon dioxide.

The composition of the envelope includes the following substances: methylene chloride, isopropanol, titanium dioxide and hydroxypropylmethylcellulose.

Tablets "Lomflox" are in blisters (5 pcs.), Which are placed in cardboard packs.

How does the drug work?

What is a Lomflox medication? Instructions for use indicate that this remedy is an antimicrobial synthetic drug. It belongs to the preparations of the fluoroquinolone group and has a wide spectrum of bactericidal action.

The drug in question is capable of blocking the DNA-gyrase of the bacteria, thereby forming a complex with its tetramer and disrupting DNA replication and transcription. As a result of such an impact, the pathogen cell dies.

This medication is active against both gram-negative and gram-positive microorganisms and aerobes. In addition, the drug adversely affects chlamydia, mycobacterium tuberculosis (intra- and extracellularly located), as well as some strains of uroplasm and mycoplasma.

In an acidic environment, the effectiveness of the drug is significantly reduced, and resistance develops very slowly.

The drug has a pronounced postantibiotic effect.

It should also be noted that streptococci and anaerobes show resistance to lomefloxacin.

Pharmacokinetics

How long is the drug "Lomflox" (pills) taken? Instructions for use say that after taking the medicine inside, the active ingredient is almost completely absorbed from the digestive tract.

When using 400 mg of the drug, its highest concentration in the blood is observed after 1.5-2 hours and is about 3.2-5.2 mg per liter. It should also be noted that when taking the drug at the indicated dosage, the concentration of Lomefloxacin may exceed the MIC for most bacteria. At least for half a day.

The association of the active substance with plasma proteins is approximately 10%. Lomefloxacin quickly penetrates into all tissues of the body. The concentration of the drug in biological fluids is 3-6 times higher than in plasma, especially in the tissues of the prostate gland, pulmonary macrophages and urine.

The half-life of the active element is about 7-9 hours. Approximately 70-80% of lomefloxacin is excreted within 24 hours (unchanged) along with urine.

In patients with impaired renal function, the half-life of the active element is significantly increased.

Indications

What diseases are prescribed Lomflox medication? The instruction for use contains the following indications:

• Diseases of the respiratory tract (infectious), or rather, their lower divisions (including exacerbations of pneumonia and chronic bronchitis);
• Infectious, as well as inflammatory diseases that were caused by bacteria sensitive to lomefloxacin;
• Otitis media;
• Chronic and acute chlamydia, mixed and gonococcal infections;
• Complicated and uncomplicated infections of the urinary and reproductive systems;
• Infectious diseases of soft tissues and skin;
• Cholecystitis and enterocolitis infectious;
• Infection of joints and bones, including chronic osteomyelitis;
• Pulmonary tuberculosis (including acute progressive forms of the disease, drug resistance of bacteria, intolerance to rifampicin, inflammatory nonspecific processes associated with tuberculosis).

It should also be noted that the drug in question is often prescribed for the prevention of infectious complications in surgical transurethral interventions.

Contraindications

In the presence of any pathologies in any case, you can not take Lomflox tablets? Instructions for use (the price of the drug is presented below) contains the following list of contraindications:

• Period of gestation and breastfeeding;
• Epilepsy, cerebral atherosclerosis, as well as conditions accompanied by convulsions;
• Children's age till 15 years;
• Hypersensitivity of the patient to lomefloxacin, as well as other quinolones.

Lomflox medication: instructions for use

The description of this tool is always available in the attached instruction. In addition, the summary to the drug informs patients about the dose at which it should be taken with a particular deviation.

Lomblox tablets should be taken orally (with water at room temperature). Its effectiveness does not depend on food intake. The usual dosage of this drug is 400 mg once a day.

In case of impaired renal function on the first day of treatment, 400 mg of the drug are prescribed, and in the subsequent - 200 mg (once a day). Dosage and duration of therapy depend on the severity of the existing deviation and the sensitivity of the pathogen.

In the event that the patient is diagnosed with tuberculosis, Lomflox tablets should be combined with such drugs as Isoniazid, Pyrazinamide and Etambutol.

It is extremely undesirable at the same time to take lomefloxacin and rifampicin. This is due to the fact that these substances are competitive antagonists.

The risk of the appearance of a photochemical reaction can be significantly reduced by taking Lomflox tablets in the evening.

Drug Interactions

Can I take Lomflox with other drugs? Instructions for use (analogues of the remedy will be presented at the end of the article) states that this drug is able to increase the activity of oral anticoagulants, as well as increase the toxicity of NSAIDs.

Sucralfate and antacids slow the absorption of the drug and reduce its bioavailability, forming chelate compounds. With regard to simultaneous administration with probenecid, it contributes to the inhibition of renal excretion.

Adverse events

Can the drug "Lomflox" affect the human body in a negative way? Instructions for use (reviews, analogs are presented in this article) states that the agent under consideration has the following side effects:

• Vessels and heart: vasculitis and oppression of the cardiopulmonary system.
• Respiratory system: pulmonary edema and larynx.
• Allergies: allergic reactions, photosensitivity, anaphylactic shock and Quincke's edema.
• The digestive tract: colitis is pseudomembranous and tenderness of the oral mucosa.
• From the liver: the development of hepatitis.
• Urinary system: polyuria, interstitial nephritis, urinary retention and renal failure.
• Muscles / skeleton: tendonitis, ligament rupture, arthralgia and myalgia.
• Nervous system (peripheral and central): anxiety, ataxia, confusion, convulsions, depression, tremor, sleep disorders, dizziness, mental disorders, headaches, hallucinations, visual impairment, taste distortion, photophobia and diplopia.
• Skin: hyperpigmentation, exfoliative dermatitis, Stevens-Johnson syndrome and epidermal necrolysis.
• Metabolism: hypoglycemia.
• Blood: hemolytic anemia and thrombocytopenia.

special instructions

What features of the drug should patients know before taking Lomflox tablets? Description of the drug, the instructions are mandatory for reading, as well as the preliminary consultation of a specialist.

With a disease such as cirrhosis, adjustment of the dosing regimen is not required. But this is only if the kidneys work is not broken.

During therapy with medication, exposure to UV rays should be avoided.

Antacid preparations, as well as vitamins and other products that contain aluminum, magnesium and iron, should not be taken two hours before and within two hours after taking the drug in question.

Does the "Lomflox" medication affect the ability to drive and operate various machinery? Instructions for use (the price of this drug is indicated in the section below) informs you that this remedy may cause a violation of attention and a rather strong dizziness. In this regard, the issue of the possibility of hazardous activities should be resolved only after assessing the patient's response to the medication.

Analogues of the drug "Lomflow", price, reviews

Instructions for the use of the funds in question were provided in this article (for informational purposes). As for the price, you can find out the exact cost only in pharmacies. As a rule, the average index varies within 500 rubles (for 5 tablets).

What else is the instruction for use about the Lomflox medication? Analogues of the drug are considered in it in some detail. According to her, this medicine can be replaced with the following drugs: Xenacquin, Okacin, Lomacin, Maksakvin, Lomefloxacin, Lofox, Lomefloxacin hydrochloride.

As for the reviews, in their majority they are positive. Patients note that Lomflox pills fight against infections quite effectively. However, it should be noted that some people who take this medication regularly complain about the occurrence of side effects.