"Genferon Light" (spray): instructions for use, reviews

When there is any malaise, you want to get rid of it as soon as possible, so finding a drug that can help in this situation in the shortest possible time, plays an important role in the selection of treatment methods. One of the tools that begin to immediately act after the introduction of acute respiratory infections and influenza, is the drug "Genferon Light" (spray), effective for both treatment and prevention of viral colds. This is due to the correct choice of the method of administration, through which the drug is delivered directly to the site of the pathogen in the body (gateway infection), as well as the composition of the drug, which includes interferon and taurine.

Pharmacological group

This drug belongs to the group of immunomodulators. It consists of recombinant human interferon alpha-2b, obtained with the strain of Escherichia coli bacteria , into which the gene of human interferon, possessing the property of increasing the protective forces of the organism, and the substance taurine, causing the antimicrobial effect, was built by genetic engineering.

The drug exhibits a complex action:

• Immunomodulating and stimulating, which consists in the harmonization and strengthening of the protective forces of the organism, manifested at the expense of alpha-2b-interferon;
• Antiviral, characterized by the suppression of the activity and the ability to propagate the causative agent of the disease at the site of its entry into the body;
• Antiproliferative, consisting in oppression of reproduction of bacteria and cancer cells;
• Mediated antibacterial;
• Anti-inflammatory.

Possessing immunostimulating and antiviral activity, the drug "Genferon Light" (spray), whose comments indicate its high effectiveness in ARVI, after introduction into the nasal passages starts to act immediately, suppressing the development of infection at the earliest stages.

Mechanism of action

Getting on the mucosa of the nasal cavity, the drug substance has a pronounced local effect in the source of infection and the overall effect on the body as a whole.

The general mechanism is due to the properties of the active ingredients contained in the preparation "Genferon Light" (spray):

• Antiviral effect is associated with the activation of intracellular enzymes that inhibit the multiplication of viruses ;
• Immunomodulating activity is due to an increase in the reactivity of the body's immune forces, which is associated with stimulation of CD8 + T-killers, NK cells, increased differentiation of B lymphocytes and the production of antibodies and other cellular immunity factors;
• Stimulates monocyte-macrophage systems and phagocytosis processes, as well as an increase in the expression of the molecules of the main complex responsible for the histocompatibility of the first type (which increases the probability of recognition of infected cells by agents of the immune system of the human body;
• The activation of white blood cells, which occurs under the action of interferon, which is part of the drug, allows to stimulate protective bodies of all layers of the mucous membrane, ensuring their direct participation in suppression of pathological foci;
• In addition, under the stimulating effect of human interferon , the production of a protective factor such as secretory immunoglobulin A is restored;
• The antibacterial effect is indirectly dependent on the enhancement of the immune response resulting from the administration of interferon;
• Normalization of metabolic processes and increase in the regenerative capacity of tissues occurs under the action of taurine, which possesses membrane-stabilizing and immunomodulating activity;
• Taurine, being an antioxidant, prevents the accumulation of free oxygen in tissues, which prevents the spread of pathological processes in them;
• Interferon, changing metabolic processes in the cells of the smallest pathogens of infections, such as viruses or chlamydia, can stop the process of their reproduction and further spread.

Form of issue

The drug "Genferon" is produced in the form of candles and a spray. The latter is a clear clear liquid, enclosed under pressure in a bottle of dark glass, ending with a dispenser equipped with a safety cap. The packaging is designed for 100 doses containing 50 000 IU of interferon alpha-2b human recombinant and 0.001 grams of taurine in each. Of the additional components can be identified disodium edetate dihydrate, glycerol, dextran, polysorbate, sodium and potassium chloride, peppermint oil, which should be taken into account if there is an individual intolerance to any of these substances. Suppositories intended for both rectal and vaginal administration are released in two dosages (120,000 and 250,000 IU), which allows them to be used by both adults and children in accordance with the need.

Indications for use

The drug "Genferon Light" (spray) showed high effectiveness in clinical studies on the treatment and prevention of influenza and other acute respiratory infections in adults and children over 14 years old, which allows them to recommend it for this purpose.

This spray can not be considered only as a remedy for the common cold, since it acts in a complex manner on the state of the whole organism as a whole, suppressing the multiplication of viruses at the site of introduction (actually the mucous membrane of the respiratory system), excluding the development of concomitant bacterial microflora and stimulating human defenses.

Such a complex action allows for many diseases to recommend the drug "Genferon Light" (spray). The instruction speaks about its high efficiency:

• As a means of treating various viral diseases, mainly the airways, and preventing their occurrence, especially during epidemics;
• As an auxiliary medicine for acute and chronic sinusitis, bronchitis, pharyngitis, laryngitis, tracheitis, tonsillitis and other diseases;
• To restore local immunity in the period after the cure for influenza and other ARVI;
• In preparation for routine surgical interventions on the ENT organs and after them.

Contraindications

The drug "Genferon Light" (spray), reviews about the treatment that testify to the effective suppression of the common cold at the initial stages, can not be used by everyone. Do not assign it:

• People who are hypersensitive to interferon alpha-2b, taurine, or other components that make up the drug;
• Children up to the age of 14, since the spray is only released with a dosage for adults;
• Patients with epilepsy or severe heart diseases.

Patients who are prone to nasal bleeding should use the remedy with caution.

The drug "Genferon Light" (spray): instructions for use, dosage

When the very first signs of the disease appear, it is necessary to begin treatment with this medication. For correct use it is necessary to observe several rules:

• After removing the protective cap, press the dispenser several times until a trickle of medicine appears (when taking the unused bottle);
• Holding the spray strictly vertically with a short push (1 dose of active substance) inject the medicine into each nostril in turn;
• To avoid the spread of infection, each bottle must be used individually.

Two schemes of application are recommended:

• According to the first, one dose of medicine is administered to each nostril three times a day for five days;
• The second option - prescribe a spray at a dose in each nostril for the first 3-4 hours, injecting the drug every 20 minutes, followed by the drug 3-4 days to 5 times a day.

The maximum allowable daily volume of the drug substance is 10 doses.

The drug "Genferon Light" (spray): instructions for use for children

This immunomodulator is released in two dosage forms - as rectal suppositories having different contents of the active substance, and in the form of a spray. It is the content of the drug base that determines the possibility of prescribing this drug to children. Candles are produced in two dosages: 250,000 IU of interferon alfa-2b, which is prescribed for adults and children over 7 years of age, and with a dose of 125,000 IU, which can be used even in the treatment of newborns. The instruction prohibits the use of the drug "Genferon Light" (spray) for children. The reviews point out the good effectiveness of suppositories in the complex treatment of acute respiratory viral infections, so many express their wishes in the appearance of a spray for children as more convenient to use. At the same time, he is allowed to appoint only when the child reaches 14 years.

Pregnancy Use

The special condition of the female body associated with the carrying of the baby requires a careful approach to the choice of drugs, since many of them are completely contraindicated to the future mother or appointed with caution if the intended use exceeds the potential risk to the fetus. Applying the drug "Genferon Light" (spray) during pregnancy is allowed at any time, since studies have not revealed the negative effect of this drug on the fetus. Conversely, if the risk of infection is high (for example, during a season of increased morbidity or in contact with people who are already ill), it is recommended that a future mother use this spray with a preventive purpose. This is due to the fact that the body of a pregnant woman is more susceptible to catarrhal diseases of any etiology due to a decrease in its resistance to the action of harmful factors.

Use of a spray during breastfeeding

The ban on the use of various kinds of medications during breastfeeding is due to the fact that the active substance, penetrating into the mother's milk, can get into the body of the child, which is especially dangerous in case of reception of funds not assigned to babies. The drug "Genferon Light" (spray) during lactation can be used, since it does not penetrate the cellular barrier of the mammary glands. On the contrary, stimulating the protective forces of the mother's organism indirectly increases the immunity in the child. In addition, although the drug "Genferon" in the form of a spray for children under 14 years old is not shown (solely because of the "adult" dosage), candles containing this substance are allowed to be used from the period of newborns with various viral infections.

Side effect

Many doctors recommend "Genferon Light" (spray) as a preventive measure. Instructions for use do not indicate specific side effects from its use. Occasionally, phenomena characteristic of any type of interferon alfa-2b, manifested by chills, fever, fatigue, loss of appetite, muscle and headache, sweating may occur. Such effects occur, mainly, when the drug is administered over 10,000,000 IU per day. The occurrence of such a reaction requires consultation with a doctor about the selection of another dose or other medication.

Compatibility with other drugs

With regard to the interaction with other substances of the drug "Genferon Light" (nasal spray), the instructions for use do not give special instructions. Almost all medications are compatible with this dosage form. The only condition is the inadmissibility of simultaneous administration of drops in the nose, designed to combat catarrhal processes in the nasal cavity, and this drug, which can reduce their effectiveness. Therefore, it is necessary to use these medicinal groups, observing the principle of separate administration.

Reviews

Most patients who used the drug "Genferon Light" (spray), say its high effectiveness in suppressing viral infections and the absence of side effects and discomfort from its use. Early application (at the very first signs of the disease) allows you to prevent the development of infection and suppress it in the shortest possible time. The only drawback is the lack of a nasal agent for children under 14 years old, since the drug "Genferon Light" for this age category, as mentioned above, exists only in the form of candles. This can cause rejection of this kind of therapy in young patients.

Thus, with the appearance of the slightest signs of the development of influenza or other acute respiratory diseases, it is recommended to immediately use the drug "Genferon Light" (nasal spray), which has antiviral, immunostimulating and modulating action, as well as anti-inflammatory effect, which will suppress the emerging disease at the very beginning and Remove all symptoms in a short time. The introduction of the drug bypassing the digestive tract allows it to be used regardless of food intake at any convenient time, while the active substance is maximally fully and rapidly absorbed at the site of administration. Intranasal use contributes to getting the drug directly into the source of infection (because the virus infections are transmitted mainly by airborne droplets), which manifests itself both locally and in the whole on the whole organism, which is due to the partial absorption of the drug into the blood through the nasal mucosa Moves.