"L-lysine escinat": instructions for use and reviews

Poorly localized complex edema of soft tissues that provoke point disturbances in the blood supply system and accompanied by painful sensations is quite a serious challenge for the pharmacological industry. Injuries of this kind are most often the result of surgical and postoperative interventions, or the result of mechanical injuries to the musculoskeletal system, the head and / or spinal cord (volume hematomas, complications with compression fractures in the form of progressive swelling, etc.).

Qualitative therapy and effective prevention of edema-pain syndrome is the "sphere of responsibility" of diuretics, glucocorticoids, flavonoids, ergot alkaloids, as well as medications obtained from the fruits of ordinary horse chestnut. In the latter case, "Lysina escinat" is of particular interest, its analogs, despite the similarity of the algorithm of pharmacological action, sometimes can not provide the necessary therapeutic effect.

The reaction of the body to the active substance

"Lysine escinate" instructions for use classifies as a multifunctional angioprotector. Components of the drug, reacting with the cells of the body, reduce the likelihood of developing large-scale inflammation, extinguish the sensitivity of pain receptors and slow the progress of puffiness in the tissues (until the complete stopping of exudative processes).

This result is possible due to the inhibition of lysosomal hydrolases, which are responsible for the rate of cleavage of mucopolysaccharides within the blood lines and in adjacent connective tissues. Moderate hypoglycemic manifestations and a general increase in the tone of blood vessels on the background of normalization of their permeability is a natural result of the dosed use of this medication.

Indications for prescription of a medicinal product

"Lysine escinat" (the instruction presents it as one of the forms of the composite association of triterpene saponins of horse chestnut) is prescribed prescription if:

• Diagnosis of swelling of the brain / spinal cord with a severe and critical degree of development (including when the presence of intracranial hematomas with displacement is confirmed);
• Local edema of soft tissues, which affect the work of the musculoskeletal system (in the patient during movement / physical exertion acute pain sensations are noted, and the damaged parts of the body are supplied with blood in the atypical regime);
• Justified suspicions about acute thrombophlebitis (there is imbalance of venous circulation of the legs, further aggravated by edematous inflammatory processes).

Lysine escinat: instructions for use and recommended dosage

Use of the medication implies a slow intravenous injection (the setting of the intra-arterial dropper is categorically prohibited). The optimal daily dose for adults is 5-10 ml of the drug, diluted with 0.9% sodium chloride solution (NaCl volume - 15-50 ml). However, in cases of a real threat to the life of the patient (usually with progressive cerebral edema) , an increase in the daily allowance of up to 20 ml of the active substance (two doses for 24 hours, 10 ml each) is permissible. The limiting dose is 25 ml / day.

To patients-children "Lizin escinate" the instruction predetermines to enter in such quantities:

• The child's age is 1-5 years: 0.22 mg per one kilogram of body weight;
• Age 5-10 years: 0.18 mg / kg;
• Age 10-15 years: 0.15 mg of the drug per kg;
• Age 15-18 years: 0.12 ml / kg.

Preparation of the active solution, that is, dilution of the drug with sodium chloride, should be performed immediately before use. The total length of therapy should not exceed 8 days (the course can be shortened to two days if the attending physician considers that the patient's condition has stabilized before the specified time).

Results of clinical trials

"Lysine escinate" instructions for use are positioned as a drug that has been clinically tested and demonstrated high effectiveness in combating edema of a different origin. Thus, in particular, in patients with a traumatic brain tumor after the administration of medication through a dropper, a significant reduction in the area of inflammation was observed. In passing, the structure of the edema also changed: the intact areas ceased to shrink, which contributed to the acceleration of the stabilization of pressure inside the skull. It was also noted that the timely injections of "Lysine escinat", performed in the form of a smooth infusion with slowed injection, often prevented the development of the above scenarios and favorably affected the patient's well-being.

Suppression of inflammatory reactions at the initial stage and prevention of volumetric swelling is reflected in the stimulation of the functional activity of the brain, that is, in minimizing the regression of nerve endings.

Special Terms of Use

Despite the fact that the reviews of profile specialists are mostly positive about the preparation "Lysina escinat", there is no reliable information on the reaction of the active components to the fetus during pregnancy (similar situation with breastfeeding of newborns). Therefore, it is not recommended to prescribe a drug in such cases.

In addition, special attention should be paid to patients with a diagnosis of "hepatocholecystitis" - escinat plays the role of a natural catalyst for transaminases and can lightly load the liver. However, in the absence of other pathologies, this disease is not a reason for drug withdrawal.

Side effects and contraindications

In addition to pregnancy and lactation, the drug "Lysine escinate" instructions for use imposes such prescription restrictions:

• Individual intolerance of components;
• Acute renal insufficiency ;
• Serious liver problems;
• Internal bleeding (ulcers or other forms of erosion of organs and tissues).

Under the above conditions, allergic reactions to the drug are extremely rare. And yet they are not excluded:

• Skin: itching, hives, the formation of bright "blush" on the face;
• Nervous system: tremor, alternating with convulsions, acute undamped headaches, fainting;
• Gastrointestinal tract : nausea, sometimes diarrhea and vomiting;
• Biliary system and liver: short-term growth of bilirubin and transaminase activity;
• Blood vessels and heart: hypotension and hypertension, arrhythmia;
• Respiratory organs: dyspnea, severe dry cough.

Quite often side effects are poorly expressed, which makes it difficult to diagnose allergies. For example, general weakness or fever can be perceived not as the result of intravenous drug intake, but as a consequence of the common cold.

The nature of interaction with other medicines

"Lysine escinat" (reviews of patients about this drug, as a rule, boil down to the topic of complications in the musculoskeletal system, since it is impossible to assess the therapeutic effect of brain injuries due to the criticality of the situation) refers to alcohol-containing compounds. Therefore, to select drugs for simultaneous use in the course therapy is necessary with increased caution (alkaloids can neutralize the active substances).

The contact of escinate with aminoglycosides is undesirable. The reason lies in the increased toxicity of the reagents. The presence of anticoagulants in the prescription makes it necessary to revise the dosage of the drug in the direction of reducing the daily norm. But the combination with analgesics and antimicrobial agents goes well (the anti-inflammatory properties of escinate intensify against the background of the lack of additional loads on organs and systems).

Form of issue and description

Being a representative of a group of angioprotectants, the drug "L-lysine escinate," whose reviews are sometimes subjective and do not reflect the real picture of what is happening, is issued as a clear, colorless solution. In this case 1 ml of liquid contains 0.001 g of active substance. The role of auxiliary components is assigned to propylene glycol, ethyl alcohol and specially prepared (injectable) water.

Overview of alternative drugs

The trade name for the described drug is Lysina escinat.

Analogs similar in pharmacological effect are presented below:

• "Furosemide" (pills / solution) - fight against edema and pain syndrome in hereditary diseases of the cardiovascular system, elimination of swelling in the areas of the brain / spinal cord (hematomas of the mechanical origin), stimulation of diuresis, etc.
• "Hypothiazid" (tablets) - with edema, provoked by congenital heart failure, cirrhosis, hypertension.
• "Valusal" (tablets / capsules / cream / solution) - for localization and neutralization of musculoskeletal degenerative processes, relief of postoperative pain syndrome, etc.

Lysine escinat: reviews of doctors and patients

Edema of interhemispheric tissues and swelling of the brain substance - evidence of severe craniocerebral trauma. According to experts, under such a situation, the structural displacement of cortical areas, which entails disability or death, is a matter of several hours, and sometimes even minutes. Dehydration therapy is usually used to stabilize the situation. However, corticosteroids, saluretics and osmotics are the most common "instruments" of influence - often provoke side effects or do not justify the hopes placed on them.

According to practitioners of neurosurgeons, the alternative preparation should be "Lysine escinat" (instructions, expert reviews and important nuances concerning the method of drug use are given above). Unlike analogues, the injection solution does not cause critical complications and precisely falls into the target, thereby ensuring control of the dynamics of puffiness (minimizes the volume of swelling of the brain / spinal cord).