The drug "Sedalgin Plus" is a combined agent that has a pronounced antipyretic, analgesic and anti-inflammatory effect. The action of this drug is based on suppression of the growth and proliferation of prostaglandins due to inhibition of the enzyme cyclooxygenase. The use of this anti-inflammatory drug can improve neural-reflex conductivity, stimulate metabolism and increase the bioavailability of analgesics. The increase in the permeability of histohematological barriers and the consequent therapeutic effect of this effect is also provided by the combined preparation "Sedalgin Plus", the price for which varies from 90 to 170 rubles.
This analgesic is given in the form of round tablets containing as active ingredients metamizole sodium, caffeine and thiamine hydrochloride.
In the role of auxiliary ingredients are substances such as wheat starch and microcrystalline cellulose. Talc is also found in the Sedalgin Plus preparation. The composition of this agent is supplemented with a small amount of silica, gelatin and magnesium stearate.
As to the field of application of this anti-inflammatory drug, it is usually prescribed for the purpose of arresting a moderate or mild pain syndrome of different genesis. For example, to eliminate migraines. When neuralgia is also shown the purpose of the combined drug "Sedalgin Plus." In addition, this anesthetic is actively used for arthralgia - joint pain, myalgia - pain in muscles, algodismenore - menstrual pains, root syndrome. Fever, very often accompanying various colds and infectious inflammatory diseases, is also the reason for prescribing these antipyretic tablets.
The main contraindications to the use of Sedalgin Plus are such conditions as renal failure, severe form of liver failure, individual intolerance to pyrazolone derivatives, increased sensitivity to metamizole sodium, caffeine and thiamine hydrochloride. In addition, one should not take this remedy to people suffering from serious blood diseases, bronchospasm, arterial hypertension, severe atherosclerosis, insomnia and increased intraocular pressure. The list of contraindications also includes pregnancy, lactation, age to twelve.
Using this drug, you must always remember about the risk of undesirable side effects. For example, some patients complain of dizziness, loss of appetite, insomnia, vomiting, nausea and increased heart rate. In addition, there may be thrombocytopenia, cholestasis, hemolytic anemia, jaundice, purpura, Quincke's edema, leukopenia, anaphylactic shock and agranulocytosis. If side effects occur, stop taking the drug.