Fluticasone furoate: instructions for use, analogues and reviews

For the treatment of inflammatory processes that occur in the human body in acute and chronic form, several types of drugs are used. Some are non-steroidal in nature, others are directly related to hormones.

What does the product work on?

The last group of drugs that effectively treat inflammation is flucatikazone furoate. This trifluorinated compound is obtained synthetically. By its nature this substance belongs to the hormones of the group of glucocorticosteroids. The medicinal component has a rather pronounced anti-inflammatory effect. Having a high level of affinity for glucocorticoid receptors, it affects different types of cells, such as macrophages, lymphocytes, eosinophils and others. Mediators of inflammation are also affected, namely chemokines and cytokines.

How does it penetrate the body?

The peculiarity of this drug is that flukacitazone furoate can not be absorbed by the body completely, as it is metabolized by the liver. Consequently, the substance is characterized by a weak systemic effect.

There are following forms of use of this medication:

• Intranasal administration. With this method of drug treatment, its bioavailability depends on the dosage. If you take the drug at 110 mcg per day, then its content in the patient's blood does not actually show up. In case of taking the drug at a dosage of 880 μg three times in 24 hours, its bioavailability is 0.5%;
• If flucatikazone furoate is taken in the form of inhalations, its bioavailability index will be 27.3%.

Also, this drug can be taken orally and intravenously.

This drug binds to blood plasma proteins with an index of 99% or more. And with red blood cells, it reacts slightly. Flucatikazone furoate is metabolically efficiently metabolized in the liver and is enzymatically digested to a harmless substance called fluticasone. This drug quickly leaves the bloodstream. If the medicine was taken orally or intravenously, it is almost completely removed from the bile from the intestine and a negligible part is excreted by the kidneys.

Indications

Fluticasone furoate, the instruction to which necessarily accompanies the package with the medicine, is indicated in the following diseases:

• Allergic rhinitis all year round.
• Obstructive pulmonary disease, including chronic.
• Bronchial asthma - as a supportive combination treatment.

If you have pronounced syndromes that are described above, then preparations based on this active substance can effectively cope with them. However, do not forget about the important fact about fluticasone furoate, that it is a hormone. Only your doctor can prescribe this medicine.

Contraindications

This pharmaceutical product has a number of contraindications and restrictions on use. It can not be taken in the following cases:

• Hypersensitivity to the main active ingredient.
• Children under 18 years of age (without special doctor's recommendation).

Limiting factors for taking this drug can be:

• Liver dysfunction.
• Pulmonary tuberculosis.
• Infectious diseases that are not cured completely or in a chronic form.

Concerning the position on whether it is possible to take fluticasone furoate for pregnant and lactating women, the instruction for use indicates that information about this is not enough. This drug should be used only in those cases where the risk to the fetus or the baby is below the expected positive effect for the mother.

Side effects

The instructions for use indicate quite extensive side effects from taking this medication, which depend on the variety of its use. With intranasal use of the drug, they are expressed as follows:

• Disturbances in the respiratory system: bleeding from the nose, the appearance on his mucous ulcers.
• Allergic manifestations: rashes on the body, Quincke's edema, anaphylaxis, urticaria.

If fluticasone furoate, reviews about which are mostly positive, used in the form of inhalations in the composition of preparations of a combined type, the following side effects may occur:

• Diseases of an infectious nature: influenza, pneumonia, bronchitis and other similar phenomena of the upper respiratory tract. Candidiasis of the oropharynx may also develop.
• Disturbances in the normal functioning of the respiratory system, which can be expressed in the form of oropharyngeal pain, nasopharyngitis, sinusitis, pharyngitis, cough, dysphonia and sinusitis.
• Diseases of connective and musculoskeletal tissues: fractures, arthralgia, pain in the back area.
• Abdominal pain, migraine, fever, extrasystole, glaucoma, decreased bone density, suppressed hypothalamic-pituitary-adrenal system functioning, delayed growth in children and adolescents, cataracts may also occur.

How to apply and how much?

Spray "Fluticasone furoate" can be taken intranasally once during the day. Also, this drug can be used for inhalations in combination preparations. Dosage of the drug is prescribed depending on the age of the patient from 27.5 to 55 mcg. To maintain the concentration of the active substance, 27.5 μg of the drug are administered.

Manufacturers of this pharmaceutical product warn that during the treatment the drug should be careful in carrying out activities that have a potential risk. These include actions requiring special attention and a rapid psychomotor reaction, such as driving a vehicle or controlling mechanisms.

Drug Interactions

When using fluticasone furoate with ketoconazole concomitantly, caution is recommended.

Also, simultaneous joint reception with "Ritonavir" is not recommended. This is explained by the risk of increasing the systemic effects of fluticasone furoate.

Overdose

In a study of the likelihood of an overdose with this drug, patients received a dose that exceeded the recommended dose by 24 times over a period of more than 3 days. As a result, there were no adverse systemic manifestations. But drug manufacturers warn that the action of glucocorticosteroids may have development. In this situation, there is a need to observe the doctor and appropriate treatment, based on symptoms.

Preparations

There are several drugs on the market of pharmaceutical products, the main active ingredient of which is fluticasone furoate: Avamis, Flutisan, Nasofan, Fluteinex, Seroflo, Flohal and Flexoxonase. The most polar means of this line is the first named agent. "Avamis" fluticasone furoate contains as the main active substance and is available as a convenient spray.

Avamis

This remedy has proven itself from the very best side in the treatment of allergic rhinitis. With this disease, not only swelling of the nasal mucosa and abundant discharge from it occur, but also eye manifestations in the form of lacrimation, itching, redness and uncomfortable sensations of "sand". This symptomatology significantly reduces the quality of everyday life of a person, negatively affects its efficiency and leads to significant expenditure on therapy. Scientists have found that the main cause for allergic manifestations is the excitation of parasympathetic nerves, which mediate inflammation of the nasal mucosa. With all the symptoms of allergic rhinitis, the drug "Avamis" is doing very well. Fluticasone furoate, included in its composition as the main active ingredient, affects the active regions of the receptors of the analyzers, which as a result block the reaction of the human body to allergens. Thus, all unpleasant and even exhausting symptoms pass, and the patient's quality of life improves significantly. Due to the fact that the main component has a high degree of kinship with the receptors, their connection becomes very strong and long, which provides a lasting effect of the drug.

All contraindications and side effects of this medication are directly related to the fact that the active substance of the Avamis agent is fluticasone furoate, the instruction to which is given above. She warns that this hormonal pharmaceutical product can not be taken without the doctor's appointment.

Combined preparations

Also for the treatment of allergic rhinitis, COPD and bronchial asthma are combined preparations containing fluticasone furoate, vilantherol and some auxiliary components. The most famous in our country similar remedy is "Ellvapta Relawar". This pharmaceutical product contains active substances in the following concentrations per dose:

• Fluticasone furoate micronized, 100 mcg.
• Vilanterola trifenate micronized, 40 mcg.

This medicine is available in the form of a dosed powder for inhalation. It has a pronounced anti-inflammatory, as well as bronchodilator effect. "Ellipta's relavar" refers to agents with a bronchodilating effect, since the active components are homonids: selective beta-2-adrenomimetic and a local glucocorticosteroid.

Indications for treatment with this drug are:

• Bronchial asthma, in which the agent is used for maintenance therapy.
• Obstructive pulmonary disease in chronic form (COPD). With this diagnosis, treatment with the drug can significantly reduce exacerbations.

The described drug is intended exclusively for inhalations, which are manufactured once a day at a certain time (in the evening or in the morning). Producers recommend after the procedure to rinse the mouth with water, but do not swallow it.

Patients with bronchial asthma should take the drug, regardless of the presence of pronounced symptoms of the disease. If there are obvious manifestations of an illness during the pause between treatment courses, the doctor usually prescribes a short-acting beta ₂ -agonists in the form of inhalations. Dosage is chosen only by the attending physician.

For adults and children older than 12 years, the following concentrations of active ingredients (vilantherol triphenate and flucatisone furotate, respectively) can be given in the same inhalation / 1 time per day:

• 22 μg + 92 μg;
• 22 μg + 184 μg.

The first dosage is prescribed by a physician for those patients who require low or medium concentrations of active substances, as well as for COPD therapy in adults. It should be noted that the treatment of chronic obstruction of the lungs in children is not applied. The same dosage is prescribed for people with violations of the liver above the average level.

The second type of dosing is prescribed for patients who need a higher concentration of active substances in the treatment of bronchial asthma, when the minimum dosages do not have the desired effect.

People over 65 years old, as well as those who have kidney disease, do not need correction of the drug.

To use this medicine in the package there is a special inhaler that has nuances of operation and care. They are described in detail in the instructions and before use it is necessary to carefully study the annotation.

The side effect of the drug can be expressed in the following forms:

• Quite often: infections of the upper respiratory tract, influenza, candidiasis of the oropharynx, pneumonia; migraine; Extrasystole; Nasopharyngitis, sinusitis, rhinitis, dysphonia, cough; stomach ache; Fractures, arthralgia, pain in the back; fever.
• Rarely encountered: hypersensitivity, rash, Quincke's edema, hives, anaphylaxis; Anxiety; tremor; tachycardia.

Contraindications to the application of "Relvar Ellipta" are:

• Allergy to milk protein or to any component of the drug.
• Children up to 12 years.

With caution, this pharmaceutical product should be taken to patients with cardiovascular diseases of severe form, with pulmonary tuberculosis and chronic infectious diseases.

Pregnant women are prescribed this drug only in cases when the question of the benefits of it for the mother, greater than the risk for the fetus, is being decided. When lactation, this medication is prescribed in conjunction with the rejection of breastfeeding and the elimination of risk to the child.

Joint use of the drug "Rellar Ellipta" with beta-blockers should be avoided, except in cases of acute necessity. Also, you should be careful when combining with ketoconazole and ritonavir.

Analogues

If you can not be prescribed fluticasone furoate for the treatment of allergic rhinitis, COPD, or bronchial asthma, analogues of this medication may be an acceptable alternative. Your attending physician, based on the individual characteristics of the body, will appoint a suitable drug. Among the analogs of this drug can be noted:

• "Asmanex";
• Aurobin;
• "Garazon";
• "Dexapos";
• "Carizon";
• "Abistan";
• "Behlat" and some other drugs that are part of a single pharmaceutical group with flucatisone furotate.

Do not forget that medications should be taken only as prescribed by the doctor and only after a careful study of the instructions.