Concor Cor - instructions for use

The drug Concor Cor is manufactured in coated tablets weighing 2.5 mg. The active substance of the drug: bisoprolol hemifumarate in a ratio of 2: 1. The auxiliary substances are corn starch, calcium hydrogenphosphate, cellulose, magnesium stearate and other substances. Pharmacological and clinical characteristics. Pharmacological action is to reduce the activity of renin, significantly reduces myocardial oxygen consumption and heart rate. The drug is indicated for moderate and severe chronic heart failure. The maximum effect is shown in 1-3 hours after administration, it is valid for 24 hours. Concor Cor is prescribed when chronic heart failure is treated , but the drug is prescribed not alone, but in combination with a diuretic, an ACE inhibitor, and if necessary, a cardiac glycoside.

The dosage regimen and the duration of the drug (in mg / day)

First week 1,25

Second week 2.5

Third week 3.75

From the fourth to the fifth week, 5.0

From the eighth to the twelfth week 7.5

After the twelfth week, 10.0

Tablets are taken once a day. The maximum dose of taking the drug per day is 10 mg at a time. Tablets are swallowed whole, washed down with water. Concor Cor is recommended to be taken in the morning during breakfast or on an empty stomach. Treatment with Concor Cor is usually of a long-term nature. If necessary, the treatment can be suspended, while the dose of the drug should be reduced gradually. Side effect at the beginning of the course, the first two weeks: dizziness, fatigue, headache, manifestation of depression, sleep disturbance. It is possible to reduce tear, conjunctivitis. In some cases, bradycardia and orthostatic hypotension are possible , sensation of cold and goosebumps in the extremities. Dyspnea may occur in patients who are prone to bronchospasm. There were isolated cases of dryness of the oral mucosa, constipation, vomiting, diarrhea, nausea, hepatitis, abdominal pain. Dermatological reactions are possible - itching, sweating, redness of the skin, rash. Sometimes there are cramps in the legs, muscle weakness. In patients with psoriasis, its course may worsen.

Contraindications for use

Concor Cor does not apply to cardiogenic shock, acute heart failure, in the stage of obvious decompensation in the presence of chronic heart failure, collapse, AV blockade II, III degrees, sinoatrial blockade, SSSU, Prinzmetal angina, pronounced bradycardia (more than 50 beats per minute) expressed Decrease in blood pressure (less than 90 mm of mercury), severe bronchial asthma, Raynaud's disease, metabolic acidosis. The safety and effectiveness of the drug when used in childhood and adolescence have not yet been established.

Application during pregnancy

During pregnancy and during lactation, Concor Cor preparation should not be used, experience with this category is not enough. If the drug is used in some cases in pregnancy, its use should be stopped, at least seventy-two hours before the expected delivery. Because there is the possibility of bradycardia, a decrease in the blood sugar content and respiratory depression in a newborn. If the fetus has other problems with the vascular system, the drug may aggravate them.

Overdose

Symptoms of overdose are bronchospasm, hypotension, bradycardia. It is necessary to cancel the medication, take a sorbent and urgently call a doctor.

Terms and conditions of storage

The medicine Concor Cor is stored in the presence of a temperature of not more than 25 ° C. The storage location should be out of the children's access area, as there is a risk of poisoning. The period of suitability of Concor Cora is 3 years.