What helps "Hypothiazid." "Hypothiazide": instructions, reviews, analogues

Today we will tell you about what helps "Hypothiazid"? Also, in the materials of this article will be given instructions on the use of this drug, consumer feedback, the form of its release, properties and so on.

Description of the preparation, form, packaging and composition

What helps Hypothiazid? Before answering the question, it is necessary to tell, in what form this drug goes to the pharmacies.

"Hypothiazide" is available in the form of white tablets (may have a greyish shade). They have a round and flat shape, risk on one side and engraving "H" on the other.

The active ingredient of this drug is hydrochlorothiazide. It also includes auxiliary elements in the form of magnesium stearate, lactose monohydrate, talc, gelatin and corn starch.

In the sale of this product comes in blisters, which are packaged in cardboard boxes.

Pharmacological action

What is the drug "Hypothiazid"? What helps this medicine?

According to the instructions, the drug in question is a diuretic. Its primary mechanism of action is an increase in diuresis by inhibiting the reabsorption of chloride and sodium ions in the initial region of the renal tubules. This effect leads to an increase in the excretion of chlorine, sodium and, as a consequence, water.

It should also be noted that after the intake of this drug increases the excretion of other electrolytes, or rather, potassium and magnesium.

In large therapeutic doses, the natriuretic and diuretic effects of this drug are the same.

Diuresis and natriuresis occur within 120 minutes and reach a maximum value after 4 hours.

It should also be noted that this drug reduces the activity of carbonic anhydrase by increasing the excretion of bicarbonate ions. However, this action of the drug is weak and does not affect the pH of the urine.

The active substance "Hypothiazide" has hypotensive properties. It should also be said that the agent in question does not affect normal blood pressure.

Kinetics of the drug

Is the drug "Hypothiazid" absorbed? The instruction, the description of the drug report that hydrochlorothiazide is not completely, but very quickly absorbed from the digestive system. This action lasts for 6-12 hours.

When taking the drug inside at a dosage of 100 mg, its peak concentration in the plasma is reached after 2.5 hours.

The connection with plasma proteins is 40%.

According to experts, hydrochlorothiazide is excreted along with breast milk and penetrates the placental barrier.

This remedy is excreted by the kidneys within 6 hours.

Medication: "Hypothiazid": what helps?

This tool is prescribed for:

• Prevention of the formation of stones in the urinary tract in persons predisposed to this disease (in order to reduce hypercalciuria);
• Arterial hypertension (for monotherapy and in combination with other antihypertensive drugs) ;
• Control of polyuria (mainly in non-sugar nephrogenic diabetes);
• Edematous syndrome of various origin (premenstrual tension syndrome, nephrotic syndrome, chronic renal failure, acute glomerulonephritis, treatment with corticosteroids, chronic heart failure, portal hypertension).

Contraindications

About that, from what "Hypothiazid" helps, we have told above. You should also know about the contraindications of this remedy. They include:

• Children up to three years;
• Severe renal failure;
• Anuria;
• Hepatic failure in severe degree;
• Addison's disease;
• Diabetes mellitus is difficult to control;
• Refractory hypokalemia, hyponatremia, hypercalcemia;
• Increased sensitivity to the elements of the drug and derivatives of sulfonamides.

With special care, this remedy should be used in IHD, hypokalemia, liver cirrhosis, hyponatremia, gout, hypercalcemia, cardiac glycosides, lactose intolerance and in elderly people.

The drug "Hypothiazide": instructions for use

Reviews, analogues of the drug in question are presented at the end of the article.

Tablets should be taken after a meal. Their dose is selected in the course of treatment, individually.

Initial dosing of the drug for adults:

• Syndrome of premenstrual tension: taking the medication begins with the appearance of the first signs before the onset of menstruation (in the amount of 25 mg once a day).
• Edema syndrome of various origin: 25-100 mg once a day or once every two days. In severe cases, the drug is prescribed at 200 mg.
• Arterial hypertension: 25-50 mg once a day. The therapeutic effect of this drug manifests itself within 4 days.
• Non-diabetes diabetes nephrogenic: 50-150 mg per day (in several receptions).

As for children, for them the drug in question is prescribed taking into account weight. The daily dosage is 1-2 mg / kg.

Adverse events

Now you know what Hypothiazide helps with. Against the background of taking this medicine, the following side reactions may develop:

• Anorexia, dry mouth, muscle cramps, diarrhea;
• Pain in muscles, constipation, fatigue, cholecystitis, weakness, cholestatic jaundice;
• Lethargy, pancreatitis, thirst, sialadenitis;
• Arrhythmia, aplastic anemia, vasculitis, thrombocytopenia, headache, leukopenia;
• Dizziness, hemolytic anemia, functional kidney disorders, agranulocytosis and others.

Analogues and reviews about the drug "Hypothiazid"

Reviews of "Hypothiazide" report that this is an effective and quick-acting diuretic. The intake of such tablets prevents the formation of stones in the urinary tract, reduces blood pressure and eliminates swelling of various origins.

The disadvantages of the drug in question include a large number of adverse reactions.

Similar drugs of this drug are: "Hydrochlorothiazide", "Hydrochlorothiazide-SAR", "Dichlorothiazide", "Hydrochlorothiazide-Verte" and others.