"Tsifran ST": analogues, instructions for use and price

"Tsifran ST" - a combined drug with active substances tinidazole and ciprofloxacin. It is intended for the treatment of infectious diseases of the gastrointestinal tract and mixed infections, the development of which was facilitated by aerobes and anaerobes.

Several forms of the preparation "Tsifran" are being manufactured. Forms of release of a medicine - tablets in a cover, eye drops, a solution for infusions.

Tinidazole is formed from imidazole. The drug has antimicrobial and antiprotozoal action, it is used for diseases caused by anaerobes.

Ciprofloxacin refers to antibiotics that have a wide range of actions. To him, sensitive aerobes (most aerobes, which are Gram-positive, Gram-negative).

Both the original and analogues of "Tsifran ST", effectively cope with the tasks.

Pharmacodynamics

Tinidazole, which has an effect on anaerobes, is effective in treating the affected lung, organs located in the oral cavity, in the peritoneum and the pelvis.

Since anaerobic infections are mainly mixed (developed under the influence of aerobes and anaerobes), the drug contains an antibiotic ciprofloxacin, which acts depressingly on bacteria belonging to aerobes.

Pharmacokinetics

The main substances, which make up the original preparation and analogues of "Cyphran ST", are well absorbed into the digestive tract and spread through tissues, liquid media. Their maximum concentrations are observed in the body on average 1.5 hours after penetration of the drug into the digestive tract.

Tinidazole has a bioavailability of 100%, partially excreted in 10-12 hours. The connection with blood plasma proteins is insignificant - 12%. There is excretion in the bile, about 25% of the tinidazole is excreted from the body with urine in an unchanged form. Metabolites are eliminated in the same way. An insignificant part of the component leaves the body with feces.

Ciprofloxacin with a bioavailability of approximately 70% is best absorbed when used internally. Penetrating into the body with food, the component that has in its composition "Tsifran ST" (analogous to active substances) is absorbed more slowly. Ciprofloxacin binds to plasma by 20-40%. Partial metabolism occurs in the liver, half of the accepted dose penetrates into the urine, is excreted unchanged. About 15% of ciprofloxacin takes the form of metabolites and is excreted in this form, 15-30% are removed with feces, the rest - with bile. For partial elimination, an average of 4 hours is required, but this period may be longer in elderly patients and if the patient has severe renal impairment.

Indications for the use of the drug "Cyphran ST"

Let's consider, in what cases allows the use of the means "Tsifran" instructions for use. The price and analogues of this drug determine the effectiveness of treatment for the following diseases:

• Mixed infections, the development of which occurred under the influence of bacteria (aerobes and anaerobes);
• Diarrhea and dysentery of different etiology (amoebic, mixed (bacterial and amoebic)).

The drug is suitable for the treatment of such mixed infections:

• Infectious processes occurring in the organs of the oral cavity (including periostitis, periodontitis);
• Pressure sores;
• Trophic ulcers with diabetic foot syndrome;
• Infectious processes affecting soft tissues, skin;
• Osteomyelitis in chronic form;
• Infection, resulting from surgery and caused by exposure to bacteria (aerobes, anaerobes);
• Gynecological diseases of an inflammatory nature;
• Infection in the peritoneum;
• Empyema;
• Abscess of the lungs;
• Sinusitis, which passed into a chronic form.

Contraindications

Not all cases can be taken "Tsifran". Reviews, analogs will help you choose the right treatment options.

The instruction prohibits the use of the drug in the presence of certain problems:

• Organic diseases of the central nervous system;
• Acute porphyria;
• Pathology of the bone marrow (disrupted the process of hematopoiesis);
• Blood diseases (in history).

Contraindications are also hypersensitivity to the components of the drug, the bearing of the child, breast-feeding. The medication is not prescribed for patients under 18 years of age. Instruction "Tsifran ST" does not allow the use of alcohol.

Taking medication in the elderly has some peculiarities, so you should always follow the recommendations of your doctor. Caution is required when:

• Pronounced disorders in the liver and kidneys;
• Convulsive conditions (anamnesis);
• Epilepsy;
• Mental illness;
• Violation of blood circulation in the brain;
• Atherosclerosis of vessels located in the brain.

Use of the drug, dosage

"Tsifran ST", an analogue of a medicinal product have different methods of application and are used in different doses. The original preparation, intended for internal use, is taken after a meal (twice daily). "Tsifran ST" is washed down with a lot of water. It is forbidden to violate the integrity of a pill, you need to drink it whole.

The recommended dose for adult patients is:

• Tablets, in which ciprofloxacin and tinidazole are present at 250 and 300 mg respectively - 2 pieces;
• Tablets with ciprofloxacin and tinidazole at 500 and 600 mg - 1 piece.

When using the drug locally for an inflamed eye, one or two drops of the drug are required. Treatment should be done at intervals of 1-4 hours. If the condition improves, the interval can be increased.

Side effects of the drug "Cyphran ST"

"Tsifran ST" (equivalent to the basic substances) can provoke some unwanted reactions.

The digestive system:

• Hepatonecrosis;
• hepatitis;
• Jaundice cholestatic (the highest risk of its development in patients with a diseased liver);
• Diarrhea, flatulence, pain in the abdomen;
• nausea and vomiting;
• Unpleasant taste of metal in the mouth;
• Poor appetite;
• Dryness of the mucous lining the oral cavity.

Nervous system:

• Thrombosis affecting the cerebral arteries;
• Fainting;
• High ICP;
• migraine;
• Dizziness, headache;
• Psychotic reactions;
• Increased sweating;
• Lack of sleep;
• tremor;
• Weakness, fatigue;
• Convulsions;
• Peripheral neuropathy;
• Dysarthria;
• Problems with coordination of movements.

He also notes other undesirable manifestations of "Tsifran ST" instruction. Price in pharmacies, analogs determine not only the effectiveness of the drug, but also the presence of some side effects.

Sense organs:

• Deterioration of vision;
• Change of sense of smell;
• A violation of taste sensations;
• Poor hearing.

The cardiovascular system:

• Low blood pressure;
• Changes in the rhythm of the heart;
• tachycardia.

The urinary system :

• Interstitial nephritis;
• Problems with excretion of urine;
• The formation of excessive amounts of urine;
• Defeat of the glomeruli of the kidneys;
• The excretion of urine with the formation of salt crystals in it;
• The determination of blood in the urine.

Possible manifestations of allergies and other undesirable effects, changes in laboratory indicators, various disorders in the hematopoietic system.

Drug Interactions

"Tsifran ST" (an analogue for active components) should not be combined with "Ethionamide". The drug is combined with some antibiotics and sulfonamides.

When used with "Phenobarbital", metabolism is accelerated. The drug enhances the effect of ethanol and anticoagulants.

special instructions

During the period of therapy, it is necessary to stay as rarely as possible under the action of sunlight. It is forbidden to engage in activities that, when treated with the drug, may endanger health (requires cautiousness, rapid manifestation of motor and mental reactions). During therapy, peripheral blood should be monitored.

Analogues, reviews, price

When appointing "Tsifran ST" analogs, the price is important for patients. The most commonly used tablets. The cost of tablets with a content of basic substances of 250 and 300 mg is about 36-460 rubles, the price of tablets, where there are 500 and 600 mg of the main components - about 79-500 rubles.

What can replace "Tsifran ST"? Analogues Russians are cheaper. The original drug can be replaced, for example, with "Ciprofloxacin" (10-25 rubles). From Indian analogues, you can choose "Tanidazol + Ciprofloxacin" or "Ciprolet A" (150-325 rubles). It is these drugs that are mainly replaced by Cyfran ST.

Judging by the reviews, the original drug copes well with a cold, especially if the disease is started. When used in the early days of the menstrual cycle, it can cure many female inflammations. "Tsifran ST" quickly enough facilitates a condition of the patient.

In general, the antibiotic is used after the operations and in those cases when the body has serious inflammations that do not disappear for a long time, since there are a lot of side effects. In the reviews, buyers note that the analogs are no less effective and are easier to transfer.

The drug "Tsifran ST" is taken only after examination and appointment by a doctor. Do not self-medicate, because the consequences can be serious.