The drug "Mercazolil", instruction

The drug is released in the form of tablets. Pharmacological action is based on
Antithyroid properties of the active substance - thiamazole (5 mg in 1 tablet). The drug "Merkazolil", doctors' reviews confirm this, inhibits the action of the enzyme peroxidase, without which the reaction of iodination of thyroid hormones in the thyroid gland is impossible. The result of treatment is a violation of the formation of thyroxine and triiodothyronine.

Thiamazole is well absorbed from the gastrointestinal tract. The half-life is 6 hours. Metabolized in the body, completely excreted through the kidneys.

The drug "Mercazolil", instruction

The drug is prescribed:

• With thyrotoxic crisis ;
• With diffuse toxic goiter;
• With mixed toxic goiter as part of a complex treatment with thyroid hormones or with preparations of radioactive iodine.

Medication "Mercazolil": instructions for use

The doctor chooses the dosage of the drug individually, depending on the patient's condition. Usually prescribed 20 mg to 40 mg of thiamazole per day. The daily dose is recommended to be divided into 2-4 admission. Normalization of thyroid functions is observed after a course of treatment with Mercazolil lasting from 3 to 8 weeks. After receiving positive results, the patient is transferred to maintenance therapy with thiamazole in doses from 2.5 mg to 10 mg per day.

The therapeutic daily dose of the drug for children ranges from 300 μg per 1 kg to 500 μg per kg. The maintenance daily dose of the drug for children is from 200 μg per 1 kg to 300 μg per 1 kg. The maintenance dose of thiamazole is prescribed once, in the morning after breakfast.

Means Mercazolil: side effects

During the clinical trials of the drug, allergic reactions in the form of rash or fever were rarely observed; In single patients, symptoms of lupus-like syndrome are noted.

Disorders in the work of the hematopoietic system were manifested rarely by leukopenia, agranulocytosis; In single patients, symptoms of generalized lymphadenopathy were observed.

Disturbances in the functioning of the digestive system were manifested rarely by a change in taste sensations; In single patients, liver pathology, urge to vomit and nausea were detected.

Violations in the work of the nervous system were noted only in isolated cases, manifested by neuritis and polyneuritis, headaches.

Disorders in the endocrine system were manifested by hyperplasia of the thyroid gland.

The drug "Mercazolil", the instruction: contraindications

You can not prescribe the drug:

• With severe leukopenia or granulocytopenia;
• With increased sensitivity to thiamazole;
• During pregnancy;
• During lactation.

Contraindications to the use of the drug "Mercazolil" by pregnant women are associated with its ability to penetrate the placental barrier. Therefore, the use of thiamazole after the first trimester is fraught with the development of hypothyroidism in the fetus.

Contraindications to the use of the drug "Mercazolil" breast-feeding mothers associated with its ability to penetrate into breast milk.

Medication "Mercazolil", instruction: special instructions

Treatment with thiamazole is associated with the need to regularly monitor the blood picture.

Treatment of large thyroid glands complicated by constriction of the trachea should be administered for a short time. A prolonged course of treatment can provoke the growth of the struma.

It is compulsory to consult a patient before starting treatment with Mercazolilum to explain the need to see a doctor at the first negative signs of a change in the condition. This fever, sore throat, inflammation of the mucous membrane of the mouth, the appearance of the furuncle - the characteristic symptoms of agranulocytosis.

At the forthcoming operation, the appointment of Mercazolilum is canceled in 1-2 weeks. Preparation for strumectomy is carried out with iodine-containing preparations.

It is important to consider that the lack of iodine in the patient's body increases the effect of thiamazole, and the excess of iodine lowers the effect of thiamazole.