Preparation "Metozok": instructions for use, analogues and reviews

Heart disease and blood vessels disturb many people. To eliminate these ailments, appoint Metozok. Instructions for use strongly recommend that you take this medication before using these tablets and do not take the medication yourself, as it has serious contraindications. The medicine helps with angina pectoris, severe heart failure, tachycardia, migraine and similar ailments.

Composition

Only the prescription "Metozok" is released. The instruction for use describes in detail the composition of the tablets.

The drug with a dosage of 25 mg contains 23.83 mg of active ingredient metoprolol tartrate, 50 mg contains about 47.66 mg of active ingredient, and 100 mg contains 95.32 mg.

Auxiliary substances in the drug are: hypromellose, Ludipress LCE, Povidone, Silica colloidal dioxide, magnesium stearate.

The dragee shell consists of the ready-made substance "Opadrai II", which is colored orange. It includes components such as polyvinyl alcohol, talc, macrogol, titanium dioxide, iron oxide, yellow, black and red oxide, and indigocarmine.

Tablets are a drug of prolonged action, they are covered with a light green membrane. They have a round shape, convex on both sides.

Dragee in the amount of 30 pieces packed in plastic bottles and 10 pieces in aluminum blisters. There are three blisters in the cardboard box.

The manufacturer of Methosoca is the Russian company JSC Akrihin.

Pharmacological action and pharmacodynamics

Relate to the cardioselective beta1-adrenoblockers of the tablet "Metozok". The instructions for use fully describe the pharmacological action of the drug. The drug does not have membrane-stabilizing properties and sympathomimetic activity. It is characterized by antihypertensive, antianginal and antiarrhythmic action.

In small amounts inhibits β1-adrenoreceptors of the heart, reduces the activation of catecholamines cAMP from ATP, minimizes the current inside the calcium ions, forms a negative chrono, batmo-, dromo- and inotropic effect. At the very beginning of the use of the drug, the overall resistance of the vessels increases. This is due to the stimulation of α-adrenergic receptors and the blocking of β2-adrenergic receptors. After a few days (1-3), the patient's condition returns to the initial state, and with prolonged therapy the OPSS decreases.

The antihypertensive effect occurs by decreasing the minute amount of blood flow and renin compounds due to inhibition of renin-angiotensin-aldosterone function and the central nervous system, as well as the revival of the susceptibility of the aortic arch baroreceptors, and finally the peripheral sympathetic indices decrease. The high blood pressure in a state of rest falls. Decrease in pressure occurs with physical activity and psychological stress. Antihypertensive effect lasts more than a day.

The antianginal property is manifested by a decrease in the need for myocardium in oxygen, which ultimately reduces the heart rate and the susceptibility of the muscle to the influence of sympathetic innervation. The number of seizures decreases with angina and their duration decreases. Increases the physiological activity of man. Due to the increase in the diastolic pressure in the left ventricle and the elasticity of the muscles of both ventricles, the need for oxygen in people suffering from heart failure increases.

Antiarrhythmic result is achieved by suppressing arrhythmogenic manifestations, which are expressed in the form of tachycardia, arterial hypertension, etc. There is a decrease in unforeseen excitation of sinus and ectopic rhythm and inhibition of AV-conduction.

In the presence of supraventricular and sinus tachycardia , detection of atrial fibrillation, thyrotoxicosis and other functional diseases of the cardiac apparatus, the heart rate decreases, which in some cases leads to the restoration of the sinus rhythm.

The drug is an excellent preventive against migraine.

Used in medically-therapeutic doses, it does not have a pronounced effect on organs with β2-adrenoreceptors and does not affect the metabolic processes of carbon in the body. Its effect is similar to that of Propranolol.

When taking the drug for several years, the amount of cholesterol in the blood can decrease significantly. When taking daily doses of 100 mg, the drug affects simultaneously all the β-adrenergic receptor subtypes.

"Metozok" (instructions for use comes with tablets) is absorbed by the body by 95%. Moderately soluble in fats. It is involved in presystemic metabolism, and its bioavailability is 50% with the initial use of the drug and 70% - with the following methods. The maximum concentration of the substance in the blood is observed after a lapse of 6-12 hours after the use of the tablet. In the process of constant therapy, bioavailability gradually increases. Food increases bioavailability up to 40%.

The active substance is 10% combined with blood proteins. It is quickly absorbed by the tissues and penetrates the blood-brain barrier, the placenta. A certain part of it penetrates into breast milk.

Metabolized in the liver, and the two main metabolites are characterized by beta-adrenoblocking activity. In the metabolism of the drug, the isozyme CYP2D6 is involved.

The half-life period is 3.5-7 hours on the average. The drug is not secreted by the body during hemodialysis.

In the plural, metabolites are present in patients with SC 5 ml / min, and in this case its beta-adrenoceptor activity is not increased.

Bioavailability increases with cirrhosis of the liver. Here, the overall clearance decreases.

"Metozok": indications for use

The patients' comments say that this drug facilitates the condition with tachycardia, reduces heart pain and stabilizes the state of health. Indication for the intake of tablets is arterial hypertension, as well as heart failure in a chronic form, being in the stage of compensation. In the latter case, the drug is recommended for use along with other means of integrated use.

Prescribed for ischemia of the heart medication Metozok. Indications for use occur in angina attacks (in stable form), reduce mortality and reduce the likelihood of recurrence of a second infarction, after the acute stage of the disease.

The drug is recommended for failure of the rhythm of the cardiac organ, when supraventricular tachycardia is present, to reduce the incidence of contraction of both ventricles in atrial fibrillation and ventricular extrasystoles.

The drug is effective in functional disorders of the heart, which are accompanied by severe tachycardia. It is often used to prevent migraine. These were recommended for taking the drug "Mesotoc" indications for use. Then we will talk about contraindications.

Contraindications to use

In any case, it is forbidden to take the medicine yourself, without the appointment of a doctor. Tablets are not prescribed for cardiogenic shock and AV blockade of II-III severity. Do not use the remedy for sinoatrial blockade and weakness syndrome of the sinus node. Prohibition to use is a pronounced bradycardia (50 bpm), heart failure in acute, chronic form and decompensation stage. Contraindicated "Metozok" (the instruction describes in more detail all the features of the drug) with arterial hypotension, myocardial infarction, which is in acute stage of development, severe form of bronchial asthma, pheochromocyte, peripheral circulation disorders. Categorically not advised to combine the reception of tablets with MAO inhibitors and intravenous injections of "Verapamil".

It is not necessary to use the medication for children who are under the age of eighteen years, during breastfeeding, people with lactose intolerance and intolerance, and also with malabsorption syndrome, hypersensitivity to beta adrenoblockers, including metoprolol.

With care prescribe the drug for diabetes, I degree of AV blockade and angina Prinzmetal. Alertness should cause metabolic acidosis, bronchial asthma, as well as diseases of the pulmonary, hepatic and renal system. Practically they do not prescribe medicine for myasthenia gravis, pheochromocytosis, thyrotoxicosis, depressive state, psoriasis, peripheral circulatory malfunction, during pregnancy and elderly people.

There were no clinical studies on the effect of the drug on pregnant women. There is also no data on the extent of penetration of the drug into breast milk. Therefore, during the period of bearing and lactation before consuming tablets, one should consult a doctor.

Metozok: instructions for use

Comments from some patients indicate that the drug may cause a side effect in the form of rapid fatigue. Therefore, it is important to follow the rules of admission and the recommended dose. If the doctor did not pick up the treatment individually, then you should drink the "Metozok" tablet according to the classical scheme. Instructions for use recommend the use of the drug once a day in the morning, regardless of food intake. Dragee is not chewed and washed down with a small amount of water. In order not to have a bradycardia, the dose of the medicine is increased gradually.

In the presence of angina and hypertension, treatment begins with 50 mg per day. If the effect was not achieved, then the daily dose is raised to 100-200 mg / day, and in case of hypertension - in some cases - therapy is supplemented with another hypotensive drug.

For people with chronic heart failure class II, according to the NYHA classification, without the stages of exacerbation for half a year and without significant changes in complex treatment for the last fourteen days, an initial dose of 25 mg once a day is provided. Two weeks later, if necessary, the daily dose is increased to 50 mg, and then, after two weeks, to 100 mg and increased to 200 mg after the same interval (14 days).

With the III-IV class of chronic heart failure, treatment starts with 12.5 mg once a day and only after two weeks this amount is increased to 25 mg, and so on - until the maximum daily dose of 200 mg. With this diagnosis, a patient with a therapeutic dose increase should be under close supervision of a doctor, as in some patients the condition may worsen.

Apply the drug in the repeated prevention of myocardial infarction and cardiac rhythm failures in the therapeutic daily dose of 100 mg.

Patients with functional disorders of the heart, in which there is also a tachycardia, the drug is prescribed at 50 mg per day. If necessary, the daily dose is increased to 200 mg.

To prevent migraine, the drug is recommended to drink 100-200 mg per day.

Do not adjust the therapeutic dose to the elderly and patients with renal failure, who are on hemodialysis.

Liver disease has an effect on the removal of metoprolol from the body, so in this case, during treatment, the therapeutic dose is adjusted regardless of the patient's condition.

Overdose

It is necessary with caution and only with the doctor's prescription to take Metozok tablets. The instruction describes contraindications, in which taking this medication is not possible. Experts emphasize that if the doses and reception rules are not observed, an overdose may occur with the drug accompanied by ventricular extrasystole and tachycardia, a sense of heaviness in the head, arms and legs, and a significant increase in blood pressure.

Treatment is carried out by intravenous injections of alpha-adrenoblockers and beta-blockers.

Side effects

As already mentioned, in some cases, when taking the drug "Mesotoc" may be observed side effects. According to patients, this may be an increase in blood pressure, acceleration of the heart rate, fibrillation of the heart ventricles, arrhythmia, cardialgia and bradycardia.

From the central nervous system can be observed dizziness, unconscious feeling of fear, anxiety, sleep disturbance, headache, muscle cramps, tremor, cerebral hemorrhage, paresthesia.

Other side ailments, judging by the opinions of doctors and their patients, include such symptoms as pallor of the skin, ischemia of the skin in the injection zone, allergy, necrosis, scab on the surface of the tissue after the injection of subcutaneous injections.

In case of appearance of side effects advises to cancel the drug "Metozok" instructions for use. Analogues to this medicine will help to choose the attending physician.

special instructions

They are of great importance in the appointment of the drug "Metozok" indications for use. Analogues are used to treat such diseases is not so rare. They are selected by a specialist, carefully assessing the patient's condition, in the event that the "Mesotok" for certain reasons is not approached.

Throughout the treatment, it is necessary to closely monitor the cardiogram indices, arterial pressure, blood circulation in the hands and feet, and also for the minute volume of blood.

Patients suffering from hypertension with acute heart failure need to maintain a systolic blood pressure of 30-40 mm Hg. Art.

With an increase in blood pressure, accompanied by symptoms of tachycardia or bradycardia, heart rate irregularities are sometimes observed. In such a situation, the treatment with "Metozok" (the instruction warns about possible side effects) should be stopped. To prevent a secondary decrease in blood pressure after drug withdrawal, the dose is reduced gradually, especially if there has been a continuous infusion, and droppers continue to be delivered to the patient if the pressure drops to 70-80 mmHg. Art.

In elderly people, the number of adrenoreceptors particularly susceptible to phenylephrine is reduced. In turn, monoamine oxidase inhibitors, increasing the squeezing effect of sympathomimetics, provoke pain in the head, arrhythmia, gag reflex, hypertensive crisis. As a result, patients using monoamine oxidase inhibitors decrease the number of sympathomimetics within 2-3 days.

During the course therapy, doctors do not recommend performing dangerous activities, based on the speed of the reaction - both mental and physiological.

With extreme caution, people with kidney disease and elderly people should take pills. The drug should not be taken to children under the age of eighteen because of insufficient knowledge of its influence.

The medicine is released from the pharmacies strictly according to the doctor's prescription.

Analogs of the medicinal product

What should I do if, for some reason, Metozok did not approach? Analogues can always be found in the pharmacy. They have exactly the same active substance and similarly affect the body. These drugs include:

• Betalok.
• "Serdol".
• "Egilok S".
• "Vazocardin retard."
• Metoprolol.
• "Corvitol 50".
• Metocard.
• "Emzok".
• "Athenolol."
• "Lidalok".

These and other substitute "Metozok" analogues are successfully used in the treatment of cardiovascular diseases. All means require a serious approach, and they can not be taken independently, without a doctor's order.

Patient Reviews

The drug "Metozok" reviews has mostly positive. People note that it is convenient to drink (the recommended dose is one tablet a day). They say about its effective action. Many patients claim that after using the remedy they forgot about the pains in the heart.

Specialists in the field of medicine also praise in every possible way the tablets of Metozok. The doctors' comments indicate that this medicine is effective and safe, therefore it is often prescribed by cardiologists to its patients. Experts say that during treatment the main thing is to choose the right dose, otherwise side effects can occur in the form of fast fatigue, nausea, vomiting and diarrhea.