Preparation "Divigel": reviews, description, application

Gel transdermal application "Divigel", reviews of which are extremely numerous, is an anti-climacteric synthetic drug prescribed for symptoms of acute estrogen deficiency. In its essence, it is a means of hormone replacement therapy, because its active ingredient - synthetic estradiol - is chemically and biologically identical to the natural female sex hormone.

The drug "Divigel", which reviews are mostly positive, is highly effective in long-term or cyclical treatment of women in the post-menstrual period. Due to insufficient secretion of estrogen in this phase, various body dysfunctions are manifested, manifested by sleep disorder, vasomotor instability, progressive atrophy of the genitourinary system and often osteoporosis of the spine. Exerting influence, very similar to the action of natural hormones, and stimulating the development of the vagina, fallopian tubes and uterus, the preparation "Divigel" (the reviews confirm this) eliminates completely or significantly minimizes this symptomatology.

The pharmacodynamics of this gel is as follows. In cells to which the action of the preparation "Divigel" is directed, synthetic estradiol enters into a chemical bond with specific receptors, forming with them a receptor-ligand complex and interacting with the estrogen-effector components of the genome, as well as with special intracellular proteins. This causes the induction of i-RNA synthesis and the release of various cytokines.

Thus, the transdermal "Divigel" stimulates the timely rejection of the endometrium and regular cleansing bleeding. A large concentration of the drug can promote the development of endometrial hyperplasia, suppression of lactation, inhibition of bone resorption, and stimulate the synthesis of certain transport proteins (thyroxin-binding globulin, transcortin, transferrin).

The external application of the "Divigel" (reviews testify to this) practically does not have such a side effect as an increase in blood pressure. This, of course, is a great advantage in comparison with various estradiol-containing oral medications.

The transdermal application "Divigel" with IVF is prescribed when it is required to maintain the required level of estradiol. Dosages are strictly individual and are determined by the specialists of the clinic where this procedure is carried out. Clinical studies of the preparation "Divigel" determined the nature of its compatibility and interaction with other medications. So, it became known that its active substance can reduce the effectiveness of antihypertensive, antidiabetic medications and anticoagulants. The simultaneous administration of this drug and preparations containing inducers and hepatic enzymes (barbiturates, "carbamazepine", "griseofulvin", "rifampicin" and others), can cause some decrease in estradiol in the blood plasma.

The process of treatment with the drug "Divigel", the price of which is quite moderate, should be accompanied by regular examinations. The doctor determines the frequency and set of methods in accordance with the individual clinical needs of each patient. But, as a rule, a mammogram is prescribed in the overwhelming majority of cases.

As the instruction says, the drug "Divigel" has a number of contraindications. In particular, diagnosed or suspected oncology of the mammary gland, tumoral formations of the genital organs (uterine myoma, cervical, vulvar, ovarian, etc.), endometrial hyperplasia, connective tissue diffuse pathology, climacteric hyperestrogenic phase, thrombophlebitis, liver and pituitary tumors, violation Cerebral circulation, diabetes mellitus and other diseases. Therefore, take this drug should only be prescribed by a doctor and in strictly prescribed doses.