Isoniazid. Instructions

The drug "Isoniazid" is available in the form of powder, tablets, suppositories (rectal). The active component is isonicotinic acid hydrazide.

Isoniazid is prescribed as an anti-tuberculosis drug in any form of the disease. The drug, along with the drugs "Streptomycin", "Cycloserin" and others, is used as the main drug. The medication "Isoniazid" instruction allows both children and adults to use it. More pronounced therapeutic effectiveness of the drug in acute and early stages of tuberculosis.

Medication is indicated for infiltrative forms of bronchoadenitis. Isoniazid is prescribed for miliary and subacute hematogenically disseminated pulmonary tuberculosis, exacerbation of the fibrous-cavernous form of the chronic course, tuberculous intoxication and lupus, tuberculosis of the larynx, mucous digestive tract, oral cavity, serous membranes, genitourinary system, joints, bones.

There is no pronounced therapeutic efficacy in patients with old cirrhotic pathology.

For the treatment of a mixed type of infection, the drug "Isoniazid" recommends the instruction to be prescribed together with the corresponding sulfonamides and antibiotics.

The medicine is taken three times a day for 0.2 grams after meals. In case of good tolerance, an increase in the dose to 0.9 grams per day (three times 0.3 grams per day) is permissible. With a body weight of less than 50 kg, no more than 0.15 grams is recommended three times a day.

Maximum per day allowed to take 0.9 grams, for one reception - 0.6 grams. Intramuscular injections and suppositories are used in the same doses, drip intravenously, 0.01-0.015 g / kg in the form of a 0.2% solution.

Contraindicated in patients who are prone to convulsive conditions, vascular disease, mental illness, as well as having syphilitic damage to the nervous system.

Be careful when prescribing the drug "Isoniazid" instruction recommends that the patient has violations of the liver, kidneys, nervous peripheral system, optic nerve.

Possible side effects when using the drug should include polyneuritis, paresthesia, memory loss, insomnia, euphoria, irritability, headache. In addition, in some cases there are muscle twitchings, dizziness, convulsions. To the negative manifestations when using the drug "Isoniazid" the instruction includes ataxia, fever, stupor, dry mouth, rash, hepatitis, and urinary retention (in men). Rarely anemia, pellagra, jaundice, eosinophilia occurs.

In the pharmacy, as a rule, a prescription is required for the purchase of the preparation "Izoniazid".

Recommended actions for complications and poisoning

To eliminate the consequences of taking "Isoniazid" medication (including in elevated doses), the drug "Pyridoxine hydrochloride" is prescribed. The introduction is carried out intravenously. The dosage of "Pyridoxine hydrochloride" is set at a rate of one gram per gram of "Isoniazid" preparation. In case the accepted amount of the latter is unknown, mix five grams of the drug "Pyridoxine hydrochloride" and fifty grams of isotonic sodium chloride solution. Such a solution is administered for five minutes intravenously, and then again after twenty to thirty minutes, until the consciousness returns and the seizure condition is eliminated.

In case of poisoning or overdose, gastric lavage is prescribed by suspension of activated carbon or provocation of artificial vomiting. Saline laxative is shown . Artificial respiration is used. Prescribe medication "Prednisolone", transfusion drugs, intravenously solution "Sodium Hydrocarbonate" (3-5%) for fifty-one hundred milliliters. To eliminate seizures, intravenously slowly injected "Sibazon" (probably hypersensitivity) or barbiturates of short-term exposure. The preparations "Cyanocobalamin", "Methionine", "Thiamin" are shown.

The medicinal preparation "Isoniazid" has the following analogs: "Tubazid", "Rimicid", "Zonazid", "Kotinazin", "Ditubin" and others.