Interferon inductors, preparations for children: list, action. High-speed inducers of endogenous interferon

In order to prevent and treat viral diseases, inducers of interferon are used. The mechanism of their action is associated with the production of protein substances, which prevent the multiplication of pathogenic pathogens. Preparations based on inducers allow to fight with respiratory diseases, herpetic and hepatitis infections, influenza.

Definition of interferon

This is the name for a group of compounds having a protein origin. They are produced by cells that are infected with viral pathogens.

Interferon substances belong to the factors of the nonspecific protective mechanism in the body against bacterial, chlamydial, pathogenic fungal infections, cellular structures of tumors. They also play the role of regulators of intercellular interaction of systemic immunity. They are also called immunomodulators with endogenous nature.

There are several forms of human interferon substances: leukocyte, or a-interferon, fibroblastic, or b-interferon, and immune, or g-interferon.

The scheme of the mechanism of their work begins with the binding of proteins and receptors of a specific nature in cells. With this interaction, protein molecules are synthesized within three dozen. With the help of regulatory peptides, stimulation of T-lymphocyte activity and macrophage structures is carried out, viruses are prevented from penetrating the cell membrane and multiplying them. They are responsible for the protective properties.

Natural interferon inducers are viral cells that have penetrated into the living organism. They are strong and weak stimulants for producing protective protein. Most pathogens of severe illnesses are poor inducers. They include cytomegalovirus and HIV infection, herpes, hepatitis forms C and B. But many pathogens that cause respiratory viral diseases are considered to be strong stimulants of protective protein production.

Interferon inductors (drugs): what is it?

Usually so called drugs of the class of synthetic immunomodulators. They are manufactured by pharmaceutical companies. Interferon inductors (drugs) are classified as a large class of compounds with different chemical structures. The active ingredient can be a low- and high-molecular substance, of synthetic or natural origin. They share a common property that allows one to induce in the cells of the body an own or endogenous interferon. Such drugs are able to exhibit antiviral and immunomodulating effects.

How it works

Inductors of endogenous interferon are drugs directed in most cases to fight against a viral infection. The mechanism of their action is based on the contact of the active substance of the drug with the cellular and tissue contents, the result of which is the production of a protective protein.

Interferon inductors are pharmaceuticals that enhance the release of protein artificially. Their action is similar to natural stimulants, which include viral, bacterial cells and various substances.

The use of interferon inducers can provoke hyporeactivity. In this state, when the drug is not administered again, the protective protein does not respond, and its suppression is observed. At this stage, it is inappropriate to administer the drug. The duration of such a state is determined by the inductor itself. The change in the active substance, as well as the interruption of treatment with the same agent, contribute to the elimination of hyporeactivity.

The administration of drugs that stimulate the production of protective protein does not cause serious undesirable consequences requiring their cancellation.

The advantage of endogenous protein inducers

There are two ways to increase the immunity of interferon. This compound can be administered exogenously or directly into the body. Another way implies endogenous interferonization with the introduction of substances that stimulate the production of its own interferon. Such a protein does not show antigenicity, which can not be said for a recombinant interferon. Prolonged introduction of ready-made protein in the form of preparations leads to the development of undesirable reactions.

Inductors of endogenous interferon in the study of their effectiveness showed pharmacological activity in a wide range of infections. Their bi-functional property, characterized by antiviral effect and pronounced immunomodulating effect, was established.

The action of inducers of interferon leads to the synthesis of proteins, which in their activity are similar to ready-made protective proteins. Such a process is considered balanced, it is controlled by mechanisms that reliably protect the body from excessive formation of these compounds.

With a single use of drugs that induce interferon, a fairly long circulation of protective protein takes place at the desired therapeutic dose. To obtain such a dosage in the appointment of an exogenous protein, it should be repeatedly administered in large volumes. Such treatment is considered more expensive.

List of drugs

Currently, doctors are increasingly using interferon inductors - drugs, a list of which every year is replenished with new medicines. A large number of immunomodulating drugs can fight many diseases.

As part of the immune system, there are functionally interrelated components that eliminate the antigenic compounds that are unusual for the body. Each element of immunity has specific agents. This explains the variety of drugs that contribute to the development of a protective protein.

There are various inducers of interferon (drugs), the list of which is headed by the drug "Poludan". This drug is considered to be the very first stimulant of protective proteins, which began to be used in the 1970s. It includes polyadenyl and polyuridic acids. Its effectiveness in the production of interferon is low. Kapljami by eye and injections of a preparation "Poludan" treat herpetic keratitis and keratoconjunctivitis. Drug solutions are made for the therapy of colpitis and herpetic vulvovaginitis.

Interferon inducers - preparations "Aktaviron", "Lavomax", "Tilaxin", "Tiloron dihydrochloride", "Amiksin", "Tiloram" - have an active component of Tylorone in their composition.

Medicines "Ridostin" and "Sodium salt of double-stranded ribonucleic acid" are released with the active substance of sodium ribonucleate.

The substance of umifenovir is a part of the medicines Arbidol, Arbivir, Immustat and Arpefly.

There are also inducers of interferon, the preparations of which are called by the name of active substances. These include tablets "Kagotsel" and "Tyloron."

Based on meglyumin acridone acetate , medicines "Meglumine acridonacetate" and "Cycloferon" are produced, and sodium oxodihydroacridine acetate is present in the drug "Neovir".

The composition of the drug "Yodantipirin" includes 1-phenyl-2,3-dimethyl-4-iodopyrazolone, and in the tablets "Alpizarin" contains the salt of the magnetrin.

Interferon inductors for children, their description

There is a large number of adult medications that can be given to a child, but only at a certain age. For example, with the drug "Cycloferon" begin to treat four-year-old children, and the remedy "Ridostin" is appointed from the age of seven. Both drugs have a wide range of effects. They are suitable for the treatment of respiratory diseases of the viral nature, the state of influenza, hepatitis chronic, herpes. Their disadvantage is the possible unwanted side reactions.

Inductors interferon - preparations for children in a special form, designed specifically for the child. Among them, the means Arbidol. It has been used since the age of two. The pediatric form of the medication is made in the form of capsules for internal administration. The drug has antiviral and immunomodulating action.

It refers to anti-influenza drugs that inhibit viral cells B and A type. With his participation, the production of internal interferon, which prevents contact and penetration of the infection inside the cell, is stimulated. Under the action of the protective protein, the lipid viral envelope is incapable of connecting to the cell membrane.

Inductors interferon for children contribute to the enhancement of immunity of the humoral type, with their action the body becomes more resistant to infectious agents, the number of complications decreases.

The drug "Kagotsel" has a similar effect on the child's body. It is produced in the form of tablets for internal use. The permissible age of use of the drug is from three years.

Therapy of respiratory diseases

Interferon inductors are drugs for the treatment of acute respiratory viral infections, which lead to the formation of a protective protein in the cells of the body. They are also prescribed for influenza illness.

The most effective drugs are medications based on tyloron, which include tablets "Tiloron" and "Amiksin." For the treatment of influenza and acute disease of respiratory viral nature, adults are advised to use 125 mg at a time. This dose extends to the first two days, then 125 mg taken every other day. The course amount of the drug is 750 mg.

To conduct preventive measures, 125 mg is used at a time, then a 6-day break. This course is repeated about six weeks.

Preparations based on tylorone are contraindicated in the presence of individual intolerance, during pregnancy and during breast feeding of the child.

Taking such medicines can cause nausea, fever, an allergic reaction.

The drug "Umifenovir" has interferon-inducing activity, stimulation of cell-type immunity, increasing the resistance of the whole organism to infectious agents.

For preventive measures in contact with sick people appoint a daily dose of 200 mg for one week. During the seasonal period of influenza and respiratory diseases, a daily dose of 100 mg is used at a time, then a two-day break is made. This course lasts three weeks. For the treatment of colds, 200 mg are prescribed 4 times a day for three days.

Drugs with Umifenovir are not used in the presence of individual intolerance, during severe somatic pathologies. Taking such medicines can cause allergic manifestations.

Treatment of autoimmune diseases

These diseases include pathological conditions in which antibodies are produced or autoaggressive clones of killer cells multiply in response to healthy tissues. This leads to damage and destruction of healthy tissue, resulting in autoimmune inflammation.

Usually, interferon inducers are used for treatment. Preparations for autoimmune diseases are prescribed by those that have an immunosuppressive effect.

For the treatment of multiple sclerosis, the drug "Amiksin" is used. At the slightest manifestation of an acute respiratory infection that aggravates the condition, a dose of 125 mg or 250 mg of the drug after ingestion is prescribed. Tablets are drunk after 24 hours, duration of administration is from 6 to 12 days.

To prevent the exacerbation of multiple sclerosis, 125 mg of the drug is prescribed, 2 times every 7 days.

In complex treatment of the active phase of the disease with the signs of exacerbation, the drug is taken 125 mg 10 times per 30 days for 6 months. The drug "Amiksin" is assigned together with peptide bioregulators, the general effect of which reduces the sensitivity of the organism to the myelin protein.

Complex therapy with the drug "Cycloferon" allows you to fight arthritis with reactive and rheumatoid, systemic diseases that affect the connective tissue. His work is aimed at suppressing autoimmune processes, which provides an anti-inflammatory and analgesic effect. With the help of the device, the immune state is regulated under different immunodeficiency abnormalities. The drug "Cycloferon" is produced in tablet form, in the form of injectable solution and liniment.

For the treatment of arthritis, the drug is administered intravenously or intramuscularly once a day. Dosage of 250 mg is used from the first to the twelfth day on even days. In acute diseases, an initial increased dose of 500 mg is used.

Therapy of viral diseases

The drug "Amiksin" refers to interferon inducers of the fluorescent low molecular weight class. With his participation, all types of protective proteins are formed, the level of which reaches the highest value in plasma after a day after the application of the drug.

The drug has a large range of antiviral effects. In addition to respiratory diseases, it is used for C and B hepatitis acute and chronic forms, herpes genital recurrent, cytomegalovirus and chlamydia infection.

Many antiviral drugs - inducers of interferon, not an exception is a means of "neovir". With his participation, a large amount of protective protein is produced, especially fibroblast type, which explains the immunomodulatory, antitumor and antiviral effects of this medication. The drug "Neovir" treats encephalitis, hepatitis C and B, urethritis, cervicitis, salpingitis caused by chlamydia.

Another similar inducer of a low molecular weight protective protein is the drug "Cycloferon", for the synthesis of which carboxymethylene acrydon methylglucamine salt is used. With his participation, alpha-interferon is formed, the content of which in the lymphoid tissue persists for three days.

In T and B lymphocytes, macrophages form a protective protein, activate stem structures in the bone marrow, stimulate the production of granulocyte units. The drug is used for tick-borne encephalitis, herpes, hepatitis, cytomegalovirus, human immunodeficiency virus and papillomas.

In addition to antiviral effects, the drug is active in acute and chronic bacterial chlamydia, erysipelas, bronchitis, postoperative complications, infections of the genitourinary system, ulcerative lesions.

The drug "Lavomax" appeared on the pharmaceutical market, it is manufactured by Nizhpharm. It has an immunomodulatory effect, the ability to induce interferons, an antiviral effect of a large range.

In the tablets "Lavomax" contains 125 mg of tylorone as an active compound. The drug is an analogue of the medicine "Amiksin". Its activity is aimed at stimulating the production of three types of interferon in T-lymphocytes, hepatocytes, cells of the epithelial intestinal wall.

The influence of immunomodulatory effects is due to the restoration of the balance between immunocompetent cells and the normalization of antibody production. The mechanism of antiviral activity is based on the inhibition of the synthesis of proteins specific for viruses in infected parts of the body. This violates their further reproduction.

The drug is successfully treated with influenza, respiratory diseases, viral hepatitis and herpes rashes.

Fast acting inductors

Usually, the introduction of such medications leads to the rapid development of a protective protein.
High-speed inducers of endogenous interferon for several hours of stay in the body can cause the formation of protein, which proves their effectiveness.

The substance of Tyloron after internal application increases the protein concentration to its maximum value after 4 hours. There is a phased formation of interferon first in the intestine, then in the liver, and in a day - in the blood.

The drug "Cycloferon" induces the protein after 4 hours, and the peak is observed after 8 hours, after which the concentration gradually decreases.