"Ftoruracil" preparation: instructions for use, description, composition, analogues and reviews

Oncological diseases, unfortunately, are now very common. Naturally, you can not give up, you need to fight this pathology. In no case should you be treated yourself. Without qualified help, you can not do. The fact is that some medicines can be prescribed only by prescription and are used only by a special admission scheme. In many cases, doctors prescribe a drug such as "fluorouracil". Instructions for use of this medication will be set out below.

general characteristics

So, the presented medicine is used in oncology, since it has antitumor effect. It can be classified as anti-metabolites. That is, the substance contained in the liquid can significantly slow down the metabolism between the cells.

"Fluorouracil" (instructions for use always goes in the package with the drug) has a simple composition. It includes water sterilized and caustic soda. The main active ingredient is fluorouracil.

Forms and features of the drug

It should be noted that this medicine has several forms. If you need "Ftoruracil", the instructions for use tell us about its types:

1. Liquid solution for intravenous or intracavitary administration. Most often it happens 5% aqueous mixture in ampoules of 5 ml. There is also a concentrated solution, which is placed in a 10 ml bottle.

2. Ointment. It's usually 5% too. It is used to treat skin pathologies, for example, basal.

If you were assigned a "fluorouracil", the instructions for use contain such information regarding the reception schemes:

- Take 0.5 g / m2 each day. Or 12 mg / kg. The course of therapy is no more than 5 days. After this, a one-month break is necessary.

- Once in 7 days 0.6 g / m2. The course of therapy is about 6-10 weeks.

- In combination with other antitumor drugs - on the 1 st and 8 th day of the course, 0.6 g / m2.

However, in all cases, the dosage and method of taking the drug are individually prescribed. It all depends on the severity and stage of the disease, the general condition of the patient, his state of health, and the plan for chemotherapy.

You can inject liquid or drip. It should be borne in mind that some drugs that are given to the patient in conjunction with this, provide for a decrease in the dose of fluorouracil by 20-30%.

Pharmacological action and interaction with other drugs

So, "Fluorouracil" (instructions for use, the description of the drug must be read by the patient) has an anti-inflammatory effect and significantly slows down those chemical reactions that contribute to the division of malignant cells. That is, the substance blocks the formation of DNA.

The drug is absorbed rapidly enough, with the formation of fluorouridine monophosphate. It is split in the liver for about 20 hours. Respiratory organs (60-80%) and kidneys (7-10% in unchanged state) are involved in excretion of the drug.

If you need to take "Ftoruracil", instructions for use (the composition of the drug we have already reviewed) states that there are some substances that can not be combined with it. For example, sulfonamide drugs and phenylbutazone are incompatible with said agent. But alpha-interferon and cytostatics, on the contrary, strengthen the action of "fluorouracil". This should be taken into account when prescribing a dosage.

Note that the vaccination of the patient, due to its weakened immunity, should be carried out no earlier than 3 months - a year.

Indications for use

If you require "Fluorouracil", instructions for use (the average price of the medicine is 3000-3990 rubles) tells about such medical indications:

• Oncological disease of the small or rectum, esophagus and stomach. In this case, the drug is prescribed even with an inoperable stage or the presence of metastases.
• Primary liver cancer.
• Malignant pathologies of the gallbladder, ovaries, breast, cervix.
• Cancer of the adrenal glands.
• Oncological lesion of the prostate gland.
• Carcinogenesis or cancer of the penis.
• Tumors in the neck and head.
• Pre-cancerous condition, as well as small tumors.

The presented drug can be used even in fungal skin lesions.

What contraindications exist?

Naturally, no chemical preparation can be equally useful for all patients. And in this case the substance has some contraindications to the application.

• Too high sensitivity to some components of this tool.
• Pregnancy or lactation. This medicine has an extremely toxic effect on the fetus. If the reception is prescribed during breastfeeding, the baby is taken from the breast.
• Peptic ulcer of the duodenum or stomach, which is in the stage of exacerbation.
• Severe anemia and frequent bleeding that is difficult or impossible to stop (hemophilia).
• Leukopenia.
• Impaired functionality of the kidney or liver.
• The patient's state of health, preceded by biological death.
• Extremely severe depletion of the body.

In addition, there are some limitations. For example, with caution the drug is prescribed to those people who suffer from herpes zoster or chickenpox. Special attention should be given to the purpose of this drug if the patient is already taking cytostatics.

Possible side effects

If you are prescribed a course of a drug such as "Fluorouracil-Lance," the instructions for using this medication are practically the same as those written earlier. The issue that interests many patients are side effects. The fact is that sometimes they can be more complicated than the disease itself. So, after taking the substance, such side effects can be observed:

• Reducing the number of leukocytes and platelets in the blood.
• Nasal bleeding, which can be difficult to stop.
• Visual disturbances, neuritis of the eye.
• Nausea, which can be associated with vomiting and diarrhea. In this case, treatment should be suspended or changed.
• Stomach ulcer.
• Stomatitis.
• Partial or complete alopecia (alopecia).
• Ischemic heart disease, arrhythmia, angina pectoris, heart failure, myocardial infarction, cardiomyopathy, thrombophlebitis.
• Pain and circling in the head, increased tearing and fear of light, disorientation in space, loss of clarity of consciousness.
• Dysarthria.
• Disturbance of taste, gastric bleeding, heartburn, decreased appetite and liver function.
• Shortness of breath, cough, bronchospasm.
• Violations in the reproductive system: in women - no menstruation, in men - azoospermia.
• Hyperpigmentation of the skin, its dryness and cracking.
• Hives, skin rash, dermatitis.
• Muscle weakness, as well as the attachment of infections of various nature.

As you can see, the presented liquid or "Fluorouracil" ointment, the instructions for use of which are already clear to you, are quite dangerous medicines. In addition, some studies show the possibility of a strong toxicogenic and carcinogenic effect of the drug.

Product storage conditions

So, you have already received a lot of information about the drug presented. Now we need to consider the features of its storage. To be in the "Ftoruracil" should be in a very dark place. The storage temperature should be 15-25 degrees. Naturally, the medicine should be kept away from places accessible to children. It is not recommended to freeze liquid.

Shelf life of the drug is 2 years. After this time, the product can not be received.

There are cases when a deposit appears on the bottom of the ampoule. This occurs during long-term storage. Try to warm up the liquid to 60 degrees with vigorous shaking. Then cool the substance to 35 degrees. If the precipitate dissolves and the liquid becomes transparent again, then the preparation is ready for use.

Drug analogues

The main thing with what you need to know before taking the drug "Ftoruratsil" - instructions for use. The reviews will also be superfluous. You will learn about them later.

If the patient can not get this medicine, the doctor can assign him analogues. They have the same main active substance - fluorouracil. Now there are such analogues of this drug:

1. "Fluoro Uracil".

2. Efundex.

3. "Efu-Rix".

4. "Fluoroplex".

5. "Fluracil".

6. "Flouryl".

7. "Queroplex".

8. Timazin.

Reviews

It should be noted that this drug is used often enough. Many patients note the high effectiveness of the drug in the fight against tumors.

However, they also talk about a large number of side effects: nausea, vomiting, headache, disorientation in space. This is not surprising, since the drug is extremely toxic.

Thus, we have provided information about the drug "Ftoruracil": instructions for use, price, reviews. Remember that you can not take this medicine on your own. Be sure to consult a doctor. Otherwise, you risk harming yourself even more. Moreover, only a narrow specialist can establish a correct diagnosis after appropriate studies. Be healthy!