The drug "Lamicon": instruction, application, reviews, analogs, form of release

How much does a drug such as "Lamikon" cost? The price of this medication will be presented in this article. Also in it you will find detailed instructions on the use of the drug, its contraindications, analogs, indications, side reactions, form of release, composition and so on.

Composition, form and packaging of medicament

You can buy the drug in the following forms:

• Lamicon aerosol. The spray contains an active substance such as terbinafine. As additional components of this form, propylene glycol, cetostearyl ester of macrogol 20, benzoic acid, disodium edetate, water for injections and poloxamer 407 are used. The cuff is produced in flasks with a dosing pump of 25 g.
• Cream "Lamikon" (ointment). The instruction says that terbinafine also acts as an active element of this form. Additional ingredients of this form are: mineral oil, sodium hydroxide, white soft paraffin, cetostearyl and phenylethyl alcohols, macrogol cetostearyl ester 20, propylene glycol, poloxamer 407 and purified water. On sale the ointment comes in tubes of 15 g.
• Oral preparation "Lamicon". Tablets, the instruction of which is enclosed in a cardboard box, also contain an active substance such as terbinafine. As for the additional components, they include: corn starch, sodium starch glycollate, microcrystalline cellulose, anhydrous colloidal silicon dioxide, hydroxypropylmethylcellulose and magnesium stearate. Tablets are contained in contour cells of 7 pieces.

Pharmacodynamics

The pharmacological group of the drug under consideration is antifungal. According to the instructions, the main substance of this remedy is alilamine, which shows an active therapeutic effect on a large number of different strains of fungi.

The fungicidal properties of terbinafine (at normal concentrations) extend to dermatophytes and mold fungi, as well as some species of dimorphic fungi.

Depending on the species, with respect to yeast fungi, this medication can exhibit both fungicidal and fungistatic activity.

Operating principle

How does the "Lamicon" medication work? The instruction reports that this agent specifically inhibits the early stage of biosynthesis of sterols in membranes of fungal cells. The result of this effect is intracellular cumulation squalene, as well as ergosterol deficiency. This leads to the destruction of fungal cells.

The mechanism of action of the agent in question is directly related to the process of inhibiting an enzyme such as squalene epoxidase, which belongs to the cytochrome P 450 system.

According to reviews of specialists, the drug "Lamicon" has no effect on the effects of other drugs, as well as hormonal metabolism.

Pharmacokinetics

How is the "Lamicon" medication absorbed? The instruction states that for local or external application, the absorption of the active substance is less than 5% of the dose used. Therefore, its system exposure is negligible.

With external application, the preparation immediately begins its action and remains highly effective for a short time (approximately 8-13 days).

Due to the maintenance of the required drug concentration in the stratum corneum of the epidermis, which was obtained during therapy, the fungicidal action of the drug continues for a week after its removal.

When taking Lamicon orally, the active substance accumulates in the skin, nails and hair. The concentration of medicament in the tissues completely ensures its fungicidal properties.

Absorption of tablets is 70%, and their absolute bioavailability is 50%.

The taken preparation in an amount of 250 mg causes the greatest concentration in the blood in an hour and a half. The effective half-life is approximately 30 hours.

Food only slightly affects the bioavailability of the drug. With plasma proteins, the active substance binds to 99.5%. The drug penetrates rather quickly through the dermis and accumulates in the stratum corneum.

The allocation of "Lamicon" is carried out through the sebaceous glands. It is also found in hair, skin and hair follicles. In the first weeks of therapy, the drug penetrates into the nail plates.

Metabolized terbinafine rapidly with the participation of cytochrome P 450. After biological transformation, inactive metabolites of the drug are excreted by the kidneys.

When the liver and kidneys are damaged, the rate of terbinafine withdrawal is significantly slowed, which makes its concentration in the plasma higher.

Indications for use

What is the purpose of local medicinal forms of the drug "Lamicon"? The ointment, the instruction for which is described below, and the spray have the following indications:

• Fungal skin lesions, which were caused by fungi of the genus Trichophyton, Microsporum and Epidermophyton (dermotophytia of the feet, groin, trunk and others);
• Multicolored (or pityriasis) lichen, which arose from the effects of fungi Malassezia;
• Candidiasis of the skin, which was provoked by fungi of the genus Candida.

What is the purpose of using the oral forms of the drug "Lamikon" (tablets)? The instruction informs about the following indications:

• Fungal infections of the skin when their prevalence, concentration or severity is such that they need to be treated by the oral route (determined only by the doctor);
• Mycosis of the head and onychomycosis (damage to the nail plates).

It should be especially noted that Lamikon tablets are not used to treat varicoloured (or pitybearing) lichen.

Contraindications for use

What kind of contraindications should you know before using the drug "Lamicon"? The instruction says that the only absolute prohibition to all forms of the drug in question is hypersensitivity to its substances.

As for the period of pregnancy, childhood and breastfeeding, they are relative contraindications.

Ointment "Lamikon": instructions for use

Such forms of the drug as a spray and ointment, suggest their external application. Before using them for the treatment of fungal diseases, you must first clean and dry the affected skin.

Depending on the severity of the disease and the type of pathogen, the drug "Lamikon" (ointment) is applied twice a day. Aerosol is used at the same frequency.

The cream should be applied not only to the skin affected by the fungus, but also the areas adjacent to it. It is desirable to perform this procedure in a thin layer, gradually rubbing the ointment into the covers.

If the infectious disease is accompanied by intertrigo (for example, under the mammary glands, in the groin, between the buttocks or fingers), then the treated areas should be covered with a gauze bandage (for the whole night).

Application of aerosol

How should I use the Lamicon spray? Experts say that it is used in a sufficient amount for moistening by spraying on areas that are affected by fungi, as well as on healthy skin adjacent to them.

The duration of therapy with local drugs depends on the severity of the disease (up to two weeks).

Relief of the patient is noted in a few days. For more effective therapy, you must strictly adhere to the instructions, do not skip the next application and do not stop treatment before the due date. Otherwise, there is a high risk of relapse.

How to take pills?

The pharmacological group to which the medication belongs belongs to the instructions. He also reports on how to take this remedy.

As a rule, "Lamikon" tablets are prescribed for children from 6 years old, as well as for adult patients. The intake of the oral drug is continued until all the symptoms of the fungal disease disappear completely (depends on its nature and severity).

The sachet dosage of this medication is 250 mg for adults, and 125 mg for children weighing 20-40 kg. With a large weight, the child is also prescribed 250 mg of the drug.

The duration of therapy for trichophytosis and candidiasis of the skin is 2-4 weeks, and for dermatomycosis, the stop is 2-6 weeks.

Fungal diseases of the head are more common in children. As a rule, they are amenable to therapy, if the drug is used in a doctor's recommended dosages for a month.

Treatment of onychomycosis takes 6 weeks for the nails of the hands and 12 - for the nails of the legs. With reduced growth of nail plates, therapy can be prolonged.

Adverse Reactions

The local preparation "Lamicon", analogues of which are indicated below, can cause such manifestations as skin peeling, burning, itching, pain, irritation, pigmentation, erythema and crusting. There may also be allergic reactions.

When taking tablets, the following undesirable effects are possible:

• Neutropenia, agranulocytosis, Lyell's syndrome, pancytopenia, Stevens-Johnson syndrome;
• Thrombocytopenia, anaphylactoid reactions, flavors, symptoms of lupus erythematosus, headaches;
• Photosensitivity, paresthesia, hypoesthesia, dyspepsia;
• Dizziness, feeling of a full stomach, diarrhea, loss of appetite;
• Exacerbation of psoriasis, nausea, psoriasis-like rashes, abdominal pain, myalgia;
• Urticaria, arthralgia, rash, generalized pustulosis, hair loss, increase in the number of liver enzymes;
• A feeling of fatigue, hepatobiliary dysfunction, jaundice, hepatitis.

Analogues and cost of the drug

How much does the drug "Lamicon" cost? The price of this drug depends on its form. Ointment and spray can be purchased for 180-220 rubles, and tablets - for 370-400 rubles.

As for the analogues, among the more effective ones, there are such means as "Amorolac", salicylic acid. "Mikoseptin", "Nitrofungin", "Mikolak", "Exoderil".

Reviews about the drug

Reviews of those who used the drug "Lamicon", are extremely positive. Patients report that the therapeutic efficacy of this medication is observed a few days after its active use. As a rule, by the end of the course of therapy, the fungal disease disappears altogether.

In severe cases, doctors recommend combining dosage forms (eg, tablets and ointment, spray and tablets).

In addition to positive reports, there are negative reviews about the drug "Lamikon". Often they are associated with its inefficiency. However, experts argue that this is possible only with the treatment of mildly insensitive to the drug or its misuse. Therefore, before applying ointment, tablets or spray it is recommended to consult a doctor and establish a pathogen of fungal disease.