"Tenorik": reviews of specialists and patients, instructions for use

How does the preparation "Tenorik" work? Comments of experts and patients about this medicine you will find in the materials of the article. Also, we will describe in detail the instructions for use, tell you about the form in which the drug is manufactured, what is included in its composition, and so on.

Packaging, composition, form of the medicinal product

In what form is the medicine "Tenorik" made? Feedback from those who used this drug, says that it can only be purchased in the form of tablets. They are covered with a shell, have a biconvex and round shape with a separating risk on one side, and also have a white or almost white color.

What is the composition of the "Tenorik"? Experts' comments indicate that this drug includes two active elements: chlortalidone and atenolol.

To date, the drug is released in two different dosages. One tablet may contain 12.5 mg of chlorthalidone and 50 mg of atenolol, or 25 mg of chlorthalidone and 100 mg of atenolol.

As additional components, the composition of the medicament includes corn starch, magnesium stearate, lactose, silicon dioxide, sodium lauryl sulfate, talc, polyvinylpyrrolidone and isopropanol. As for the film shell, it consists of macrogol, isopropanol, vaseline oil, methylene chloride, titanium dioxide, talc and hypromellose.

In what packaging is the "Tenorik" medication sold? The patients' testimonies say that such a medicine can be bought both in strips and in blisters (100 or 28 pieces each) placed in packs of cardboard.

Pharmacological characteristics of the drug

Why is a drug such as "Tenorik" prescribed? The doctors' testimonies indicate that this is a combined antihypertensive drug that produces a fairly long-term antihypertensive effect.

The work of the drug is due to the action of its two components: a diuretic (i.e., chlortalidone) and a beta1-adrenoblocker (i.e., atenolol). Consider the features of these substances in more detail:

• Atenolol is a beta 1-blocker (cardioselective). Its selectivity decreases with increasing dose. It does not have internal membrane-stabilizing and sympathomimetic effects. It should be noted that like other beta-blockers, it reduces the heart rate and has an inotropic negative effect.
• Chlortalidone is a sulfonamide non-diazide diuretic. It increases the release of chlorine and sodium, and also increases the release of magnesium, potassium and bicarbonate. The antihypertensive effect of this substance is related to the excretion of sodium. Simultaneous reception of atenolol with diuretics gives more effective result, rather than application of each of these elements separately.

How long does the "Tenorik" medication work? Experts say that the effect of this drug persists throughout the day (after a single dose of medication inside the daily dosage).

Pharmacokinetic parameters

What pharmacokinetic features does the "Tenorik" drug have? The doctors' comments indicate that each of the components of the drug has its own indicators. Consider them right now.

• Atenolol. After oral administration, it is absorbed from the digestive tract by 45-50%. The greatest concentration of the active component in the blood plasma was detected after three hours. The connection with proteins is very weak and amounts to only 5-15%. Specialists have been shown that atenolol is not exposed to hepatic metabolism. More than 90% of the substance that has been absorbed into the systemic circulation leaves the body in an unchanged form through the kidneys. The half-life of this component reaches 6-9 hours. However, renal failure is often the reason for the increase in this indicator.
• Chlortalidone. After oral administration, it is absorbed from the digestive tract by 60-65%. The greatest concentration of the active component in the blood was found after twelve hours. Chlortalidone has a fairly strong bond with proteins. It is about 70-75%. The active substance is extracted by means of the kidneys. Its half-life reaches fifty hours.

Indications for use of the drug

What is the purpose of tablets "Tenorik"? The doctors' comments indicate that this drug effectively manifests itself in hypertension. However, it is recommended to be used only in complex therapy.

Contraindications to the use of tablets

Are there any contraindications to the "Tenorik" medication? The opinions of experts speak of a number of prohibitions. Let's consider their list right now.

It is highly discouraged to use this medication under the following conditions:

• Cardiogenic shock;
• Pronounced bouts of bradycardia;
• Progressive and severe arterial hypotension;
• Metabolic acidosis;
• AV-blockade of the 1st and 3rd degree;
• Violations of peripheral circulation ;
• SSSU;
• Heart failure (in chronic and acute form);
• Pheochromocytoma;
• Progressive asthma bronchial;
• Vasospastic angina pectoris;
• Diabetes diabetes;
• Bronchitis obstructive;
• Gout;
• Hypoglycemia;
• Myasthenia gravis;
• Renal failure acute;
• Acute hepatitis;
• Underage age;
• Hypersensitivity to the components of the drug.

Drug "Tenorik": instructions for use

Reviews about this medicine will be presented at the very end of the article. How should I take this medication with arterial hypertension? Adults appoint it in an amount of 50-100 mg per day. As for elderly patients, for them the medication is indicated in lower dosages.

People with impaired renal function should reduce the frequency of medication if necessary. At the same time, it is necessary to pay attention to the fact that after a long course the drug cancellation does not take place abruptly, but gradually.

Signs of drug overdose

When an overdose of this drug the patient is experiencing severe discomfort from arterial hypotension, bradycardia, heart failure, seizures, bronchospasm and increased drowsiness.

To eliminate such symptoms, in some cases, hospitalization of the patient is required, to which the stomach is washed.

Adverse Reactions

Few people know, but the drug "Tenorik" can contribute to the emergence of quite a large number of side effects. Let's list them right now:

• Bradycardia, increased symptoms of heart failure, hypotension orthostatic, cold extremities, arrhythmia, Raynaud's syndrome, AV blockade, symptoms of intermittent claudication ;
• Confusion, paresthesia, dizziness, sleep disturbance, headaches, blurred vision, mood swings, apathy, acute psychosis, hallucinations, increased fatigue, disorientation;
• Dry mouth, pancreatitis, nausea, anorexia, gastrointestinal disorders, increased liver transaminase, hepatotoxicity with intrahepatic cholestasis, constipation;
• Leukopenia, thrombocytopenia, purpura, eosinophilia, agranulocytosis;
• Alopecia, exacerbation of psoriasis, dry eyes, skin rashes, psoriasis-like reactions, photosensitivity;
• Bronchospasm;
• Hyperuricemia, hyponatremia, hypokalemia;
• An increase in the number of antinuclear antibodies, impaired glucose tolerance, and decreased potency.

Despite all the listed side effects, most often the drug "Tenorik" is tolerated by patients quite well. Side effects are so rare and weak that they are only transient.

The preparation "Tenorik": reviews of patients (patients) and specialists

The average evaluation of the drug "Tenorik" is 3.3 on 5 point system. The main advantages of this remedy are as follows:

• Effectiveness (the drug copes well with the task);
• Low cost (the medicine can be purchased only for 100-120 rubles).

As for negative reviews, there are many patients among them. Disadvantages of the drug are:

• Tablets from pressure with prolonged treatment can contribute to impotence and strong hair loss;
• The medication very often causes seizures.

According to experts, such a medicine is very effective. However, it should be taken only according to the indications and only after consultation with the attending physician. By the way, many doctors do not recommend taking this medication for elderly people. In this case, it is better to replace it with a safer means of a similar action.