Medication "Trimectal": instructions for use, price, analogues and reviews

"Trimectal", based on the active substance trimetazidine, belongs to the group of drugs with antihypoxic action and is used primarily in cardiology to stabilize the cardiovascular system. The medication is usually prescribed as a supportive / corrective agent for complex therapy and by stimulating the process of cellular metabolism contributes to the overall improvement of the patient's condition.

Form of issue and composition

There are several forms of production of the drug "Trimectal". Instructions for use suggest that it can be either hard gelatin capsules (10/20 blisters or 60-unit polymer cans) or film-coated tablets that slow release of reagents (10/20/30 pcs. Blisters). Or plastic packaging for 60/100/120 pcs.). The main component in both cases is trimetazidine dihydrochloride. However, the form of the drug, which has a lower rate of absorption and metabolism, has a different trade name - "Trimectal MB".

pharmachologic effect

Being an antihypoxic drug, "Trimectal" (the instruction for use in this plan gives a clear classification to the medicine and simultaneously emphasizes the importance of its antioxidant properties) has a direct "energizing" effect on the cardiomyocytes and neurons of the brain. Thus, the drug increases the coefficient of their functionality. Achieving the cytoprotective effect is a natural result of the growth of the cell's energy potential against the background of a complete optimization of the oxygen consumption regime.

The active substance does not allow asynchronous contraction of the myocardium by "conserving" the required minimum of phosphocreatine. If acid-base balance is disturbed, "Trimectal" controls the concentration of calcium and sodium, that is, prevents excessive accumulation of derivatives of these elements in cardiomyocytes and, in passing, normalizes the balance of potassium ions in cells. In the fight against angina, the drug manifests itself as a neutralizer of the original cause: a decrease in nitrate intake leads to the fact that after 14 days of therapy, the patients progress to resistance to physical stresses (the magnitude of blood pressure drops markedly decreases).

Absorption and metabolism

Pharmacological kinetics of the preparation "Trimectal" instructions for use describes the form of its release. So, in particular, the contents of capsules, getting inside the body, very quickly (and almost in full) is absorbed on the segment of the gastrointestinal tract. Two hours after admission, the maximum concentration of reagents in the blood plasma is noted. A single dose of 20 mg determines this figure at 55 ng / ml.

As for the degree of distribution of active components, binding to plasma proteins, as a rule, does not exceed 16%. However, histohematetic barriers are overcome with trimetazidine quite easily. About 60% of the accepted dose is excreted unchanged in the urine, with the first 50% - within 4-5 hours.

In turn, "Trimectal MB" (tablet form of production), thanks to the presence of a special coating, provides the maximum concentration of reagents in blood plasma after three hours. The half-life, depending on the age of the patients, can range from 7 to 12 hours.

Indications for use

The cases of prescription of the medicinal product "Trimectal" instructions for use determine the following:

• Prevention of angina pectoris (as an integral part of complex therapeutic measures);
• Disturbances in the work of vessels of chorioretinal nature;
• Dizziness, provoked by functional imbalances of the cardiovascular system;
• Hearing impairment (the result of ischemic processes in the vestibular apparatus).

In addition, the attending physician can make a decision on the advisability of prolonged use of the medicine in the elimination of focal erosions of the retina.

Method of application and recommended dosage

The drug is taken orally, directly during meals. The duration of the course is set by the doctor (following a detailed medical examination and diagnosis).

For the capsular form, the average norm is 40-60 mg / day (it should be used 2-3 times).

In the case of the drug "Trimectal MB" (the instructions for use in this plan are slightly different from the above recommendation), usually one tablet is given in the morning and in the evening.

Side effects

Along with the health effect, the side effects of the active components sometimes appear. Regarding the likely allergic reactions to the use of capsules of the preparation "Trimectal" instructions for use, the price of which is the patient's health, reads:

• In some patients local skin irritations may occur;
• With prolonged use of the medication is extremely rare disorders of the food system (nausea, vomiting);
• Sometimes the negative consequences of regular reception are expressed in headaches and migraines;
• The blood lines and the heart muscle are sometimes subjected to excessive loads, which indicates the need to reduce dosage.

Regarding the medicinal product "Trimectal MB" the instruction for use informs:

• The development of orthostatic hypotension and the formation of "blush" on the face is unlikely (less than one conditional patient per thousand people);
• An imbalance in the digestive tract (pain in the abdomen, diarrhea, vomiting, etc.) - quite often (more than one individual case per hundred receptions of the drug).

In addition, scenarios are not excluded when the use of tablets with modified release of reagents can become the root cause of reversible asthenia, tremor, akinesia and urticaria.

Contraindications to prescription

We are considering the antihypoxic agent Trimectal. Instructions for use, the price of the drug, the names of the medication-understudies, as well as various opinions of specialists are presented in this review with the purpose of acquainting the interested audience. This drug has a number of contraindications, equally relevant for all forms of release (capsules / tablets).

Medication is not prescribed if:

• Renal insufficiency is diagnosed (provided that CC <15 ml / min);
• The patient has symptoms of functional liver disorders;
• The patient did not reach the age of eighteen;
• There are acute allergic reactions to the components of the drug.

Among other contraindications - pregnancy and lactation.

Specific guidance and mechanism of drug interactions

"Trimectal", whose price varies widely (depending on the form of release and the country of manufacture - 300-1100 rubles.), Has not been subjected to any serious clinical research for interaction with other medical products. For this reason, it is possible to talk about the mechanism of complex combining of effects only on the basis of the conclusions obtained as a result of laboratory work with trimetazidine, the main component of the described drug. It is noted that trimetazidine plays the role of an enhancer of anti-ischemic activity, which is the result of taking other antianginal medications. Contacts of a different type with the participation of "Trimectal" reagents were not observed.

Special instructions for the purpose of the drug:

• It can not be used in the first days of hospitalization of a patient if an unstable angina is diagnosed (or pre-infarction takes place);
• The connection between the reception of capsules (tablets) of "Trimectal" and the course of Parkinson's disease, which is expressed in the strengthening / weakening of tremor, necessitates additional monitoring of the patient's condition (we are talking about periodic examinations of a neurologist);
• For patients older than 75 years, the therapeutic course is fraught with complications in the work of the kidneys, so the final decision for the doctor;
• The disturbance of psychomotor reactions provoked by trimetazidine is the basis for thinking about the appropriateness of using the medicine in cases when the patient is outside the hospital and his professional activity is associated with the threat of obtaining work-related injuries.

Overview of analogues

The most common duplicates of the preparation "Trimectal" (analogues, whose active substance is also trimetazidine):

• "Trimetazidine-Biocom MB", Russia;
• "Trimetaside", Poland;
• "Trimet", India;
• Antisten, Russia;
• Medarum 20, Russia;
• "Preductal MB", France;
• "Rimekor MB", Ukraine.

Despite the general chemical formula, the action of generics on the body may be somewhat different than that of the original. Therefore, the choice of a particular drug is the prerogative of a doctor.

The medicine "Trimectal": opinions and comments

Health problems related to the arterial arrhythmia issue are often under the focus of thematic discussions. Those who want to hear the opinions of patients and people with medical education regarding the preparation of "Trimectal" (reviews, as a rule, have a positive emotional connotation) do not have difficulties in finding information. However, a superficial analysis of opinions shows that the specificity of the appointment affects the objectivity of points of view. In fact the mentioned medicine in overwhelming majority of cases prescribe "in a complex", that is together with other medicines.

For example, a very large group of patients and, in combination, patients who underwent a therapeutic course based on Trimectal, concludes in their estimates that significant improvements in curbing such ailments as chronic hypertension and coronary heart disease have not been achieved by the drug .