"Cefoperazone + Sulbactam": instructions for use, analogues, reviews

At present, there is a huge number of infectious diseases, which it is almost impossible to cope with without the use of antibiotics. It is desirable that the drug is able to have a negative effect on a large number of microorganisms. These include "Cefoperazone + Sulbactam". Let's get acquainted with the indications for the use of this drug.

Form of issue and composition

This drug is available as a powder for the preparation of a solution. It is administered intravenously or intramuscularly. Active substance is cefoperazone in the amount of 1 g.

The drug "Cefoperazone + Sulbactam" (trade name - "Sulperazon" or "Sulperacef") and belongs to the group of antibacterial drugs.

Pharmacological action of the drug

This drug is a combination of drugs. Medication "Cefoperazone" is an antibiotic of a wide spectrum of action. It has a negative effect on most aerobic and anaerobic bacterial organisms.

The drug "Sulbactam" is an irreversible inhibitor of beta-lactamases. It does not allow the destruction of penicillins and cephalosporins, since when combined with them, it exhibits synergism.

The drug "Cefoperazone + Sulbactam" exerts its negative influence on the cells by inhibiting the mucopeptide, which is an irreplaceable part of the bacterial walls.

From the body, the drug is excreted in about 8 hours with urine. Half-life is about two hours. If the patient taking this medication suffers from liver disease, then the time for drug removal is increased.

The code of the OKPD "Cefoperazone + Sulbactam" is 24.42.11.228. Produced in India.

Indications for use of the drug

The drug is prescribed in the presence of infectious diseases, which are provoked by microorganisms that are sensitive to the active substance. These include:

• Pharyngitis.
• Tonsillitis.
• Bronchitis.
• Pneumonia.
• Abscess of the lungs.
• Infections of the urinary system, for example, cystitis, gonorrhea, prostatitis, vulvovaginitis.
• Diseases of ENT organs.
• Cutaneous pathologies of infectious nature: furunculosis, pyoderma, abscess and others.

• Infections within the joints.
• Sepsis.
• Meningitis.

The drug is also taken as a prophylaxis of complications of bacterial nature after surgical intervention.

The drug "Cefoperazone and Sulbactam Jodas" is also shown in peritonitis, cholecystitis, cholangitis and other intra-abdominal infections. The appointment of the drug and the determination of the duration of therapy and treatment regimen should only be done by a doctor.

The agent "Cefoperazone and Sulbactam Spencer" is also prescribed for the prevention.

Who does not recommend taking medication?

Despite a wide range of actions, this tool can not be taken under certain conditions:

• In the presence of hypersensitivity to the components of the drug.
• During lactation, "Cefoperazone + Sulbactam" is also contraindicated.
• Renal-liver failure requires very careful application.
• If there is a colitis in the patient's history.

Before starting treatment with this drug, it is absolutely necessary to discuss with the doctor the presence of contraindications.

Undesirable manifestations during therapy

The drug "Cefoperazone + Sulbactam", the trade name of which "Sulperazon", during treatment can cause the following side effects:

• From the side of the urinary system, hematuria may develop.
• The cardiovascular system can respond by lowering blood pressure or vasculitis.

• A blood test during treatment with the drug often shows a decrease in hemoglobin, a decrease in hematocrit, thrombocytopenia, eosinophilia, leukopenia and other abnormalities.
• Decreased albumin levels.
• Bilirubin encephalopathy is possible in newborn babies with jaundice.
• From the gastrointestinal tract may indigestion, vomiting, nausea and pseudomembranous colitis.
• On the skin can appear hives, maculopapular rash and severe itching.
• Laboratory tests show an increase in liver function tests.
• At the site of the medication, pain is possible, with intravenous injection through the catheter - phlebitis.
• The least common is headache, fever, other anaphylactic reactions of the body.

If any undesirable manifestations appear, it is necessary to discuss this issue with the attending physician. It may be necessary to revise the dosage of the drug "Cefoperazone with Sulbactam" or completely abolish it.

What to expect when an overdose of a medicine

If you take this drug under the strict supervision of a doctor, then you can not worry about an overdose, but with self-therapy this is often possible. If the body received more drugs than required, then neurological disorders, including convulsions, are possible.

Treatment in this case is carried out in accordance with the symptoms. The most effective is hemodialysis.

Treatment schedule and dosage

If a "Cefoperazone + Sulbactam" medication is prescribed, the application instruction recommends injecting the drug intravenously or intramuscularly. For adult patients, the daily dose is usually from 2 to 4 grams of active ingredient. This amount must be divided into two steps.

If the patient has a serious infection, the dose can be increased to 8 g, which also need to be divided into two doses per day. If there are no concomitant chronic diseases, most patients and a daily dose of 12-16 grams are tolerated without apparent side effects.

The duration of therapy is determined by the doctor. For example, with gonococcal urethritis without complications, administer 500 mg of the drug once.

To prevent complications after surgery, the drug is administered to the patient 1-2 g intravenously an hour before the operation. This dose can be re-entered after 12 hours. If an operation is performed with an increased risk of getting a complication in the form of infection, then the preventive administration continues for 3 days after it has been carried out.

Patients who have violations in the work of the kidneys, the drug "Cefoperazone + Sulbactam" is prescribed in a dosage of not more than 4 grams per day. In the presence of problems with the liver, this dose is reduced by another half.

Since the drug can be administered intravenously and intramuscularly, there are some features in its use.

When administered intravenously as a solvent for the powder, you can use:

• 5% dextrose solution.
• Saline.
• Sterile water for injection.

When administered intravenously, the powder in one vial must be dissolved in 10 ml of a suitable solvent. It is necessary to wait for complete dissolution and administer the drug slowly, within 3-5 minutes.

If drip administration of the drug "Cefoperazone + Sulbactam" is to be carried out, the instruction manual recommends 1 gram of the active substance. That is, the contents of one vial should be dissolved in 5 ml of water for injection, and then added to the infusion solution, bringing the concentration to 20-100 mg / ml. Given the amount of solution for drip, the duration of manipulation can be 10 to 30 minutes.

When administered intramuscularly, either water for injection or sodium chloride can be used to dissolve the powder. The ratio is usually the following: 0.5 g of the drug take 2 ml of the solvent.

Since the management of the medicine usually causes pain at the injection site, it is recommended to add the preparation "Lidocaine 2%" when preparing the solution, but only if the patient does not have an allergy to the medicine.

With any infectious disease, injections give a positive effect faster, so they prescribe "Cefoperazone + Sulbactam" in pricks. Tablets also act much more slowly.

Use of the drug in childhood

Babies often suffer from infectious diseases, in which antibiotics can not be avoided. The daily dose of the main active substance cefoperazona should be from 50 to 200 mg per one kilogram of the body weight of the child. Introduce the drug in the same parts, dividing into two steps.

It is desirable that the daily dose does not exceed 12 g. If the drug is injected, the single dose should not exceed 50 mg / kg.

Newborn babies can also be administered 50-200 mg of the drug per kilogram of weight, dividing it into two doses in 12 hours. Based on the long-term practice of using this drug in the treatment of children, it can be said that doses up to 300 mg per kilogram of body weight per day were tolerated fairly well even in the presence of bacterial meningitis.

Application of the drug during pregnancy

The drug with the active substance of cefoperazone is prescribed to women in a position only under conditions such that the benefit for the expectant mother is several times greater than the potential risk for the developing baby. If you want to use the medication during breastfeeding, the doctor will recommend for this period to transfer the baby to artificial nutrition.

Interaction with other drugs

The drug "Cefoperazone" does not combine with aminoglycosides in its pharmacological properties. If there is a need for therapy with these two groups of drugs, they are prescribed as a fractional introduction through two separate catheters.

Joint use of this drug with thrombolytic agents, antiaggregants and non-steroidal anti-inflammatory drugs increases the risk of bleeding.

For patients with problems in the work of the kidneys, taking medication "Cefoperazone Sulbactam" together with aminoglycosides and diuretics is fraught with the development of nephrotoxicity.

During therapy with the drug "Cefoperazone" it is undesirable to take alcohol, otherwise it can lead to the appearance of the following symptoms:

• Nausea.
• Vomiting.
• Strong headache.
• Tachycardia.
• Reduced blood pressure.
• Stomach ache.

Before you start treatment with this drug, you need to tell your doctor about all medications that are being taken at this time.

What to do if you have a contraindicated "Cefoperazone"? Analogues may well replace it.

Some nuances of using the drug

During treatment with this drug, one should be especially cautious of those patients who often experience allergic reactions. The risk of such hypersensitivity is fraught with even a fatal outcome. If during therapy any slight allergic manifestations are observed, the drug "Cefoperazone + Sulbactam" should be immediately canceled and replaced by another remedy.

If the patient has a severe degree of obstruction of the biliary tract, liver disease, as well as kidney problems, then an individual dose adjustment is required. In the presence of renal-hepatic insufficiency, regular monitoring of the concentration of the active substance of the drug in the blood serum is necessary. Even without control, the dose of the drug should not exceed 2 grams per day.

In some patients, during the treatment with the drug "Cefoperazone", a deficit of vitamin K developed. Most often, such a problem appeared in those who have an inadequate diet, suffers from malabsorption or for a long time is on intravenous nutrition. In patients who are treated with anticoagulants, it is always necessary to monitor prothrombin time, and if necessary, prescribe additionally the intake of vitamin K.

If a long course of treatment with the drug "Cefoperazone" is required, then an increase in microorganisms that are not sensitive to this medication is possible. Here you need periodic monitoring of indicators of the functioning of internal organs, especially the liver, kidneys and hemopoiesis. This is especially important in the treatment of newborns, infants, and premature infants.

During treatment, the drug should refrain from driving the car and performing works that require increased concentration of attention.

Drug analogues

If you consider any drug, you can call it two groups of drugs: analogs and synonyms. Synonyms include medicines, which in their composition have the same active substance. For the preparation "Tsefoperazon" such are:

• "Bakperazon."
• "Sulzenceff".
• "Sulmomer".
• "Sultsef."
• "Tsebanes."
• "Pacotsef" and others.

If you compare the drug "Cefoperazone", the analogs may have additional components that, together with the base substance, have a slightly different effect. That is why the choice of such drugs should be treated responsibly and take them only according to the doctor's prescription.

Another group of analogs includes drugs with the same pharmacological effect. If you take the drug "Cefoperazone + Sulbactam", analogues from this group are as follows:

• Powder "Azaran" for intravenous injections.
• "Axon".
• Powder for injection "Bestum".
• The "Vice".
• Claforan.

• Kefotex.
• Capsules "Tsedeks".
• "Tsemideksor" (tablets).
• "Cefantral" and many others.

Even with the same pharmacological effect, the preparations can have different effects on the body due to different active substances, so do not choose your own medicine based on the instructions for use.

Patient Reviews

Those patients who have repeatedly used the drug "Cefoperazone + Sulbactam" for the treatment of infectious diseases, note its high efficiency. Many argue that infections of the genitourinary system can be cured quickly and without complications.

Mummies babies leave about the drug "Tsefoperazon" reviews are quite positive. They noticed that the children tolerate the drug well, even with concomitant diseases. It should be recalled that such therapy should be carried out only in a hospital, especially for newborns.

The intake of any antibiotic requires increased attention to the digestive system. To maintain the balance of microflora, it is desirable to simultaneously take the appropriate drugs, for example, "Lineks." This question can always be discussed with the attending physician.