"Bol-Run" (tablets): instructions for use and reviews

Man, despite the perfection and uniqueness of his body, very often suffers from pain. Articulate, head and muscle pain can for a long time deprive him of the joys of life. The drug "Bol-Run", which will be discussed in this article, can help in eliminating the pain of different etiologies. It is produced in several dosage forms. In pharmacies, you can find tablets, ointments and creams of this brand.

There are several types of this drug that have differences in their constituent components. "Bol-Run" (tablets), for example, may have additional words in the names: "Neo" or "Premium". What are the features of these dosage forms? Are there differences in the dosage and method of taking the tablets? We will talk about this right now.

Ingredients of "Bol-Run" tablets

The drug "Bol-Run", the instruction to which will be discussed further, contains several components that act on the inflammatory processes and pain receptors. It contains a non-steroidal anti-inflammatory component of paracetamol in an amount of 500 mg. Also, each tablet contains 50 mg of diclofenac.

The composition of the tablets "Bol-Run Premium", the instructions for use of which differs little from the drugs of the same brand, besides the above components include caffeine in the amount of 50 mg and propiphenazone (150 mg), and diclofenac is absent altogether. Another difference between the "Bol-Run" and "Bol-Run Premium" tablets is the amount of paracetamol. If the first drug contains 500 mg, then the second - 250.

In addition to the active ingredients, all Bol-Ran tablets contain a standard set of auxiliary components: starches, parabens, dyes and cellulose.

Leave from pharmacies and storage of tablets

From pharmacies the medicine is dispensed over-the-counter. However, it is recommended to take it strictly according to the doctor's prescription. Keep the instruction "Bol-Run" (pills) instruction away from heating devices and direct sunlight. The maximum permissible temperature is 25 degrees. The storage time should not exceed the time limits indicated on the medicine package. After this period of time, the tablets are disposed of together with household waste.

Pharmacokinetics and pharmacodynamics of the drug

Impact on the body of the drug "Bol-Run" instructions for use connects with the properties of all its components. Paracetamol and diclofenac block the synthesis of prostaglandins, thereby reducing the severity of pain symptoms and inflammation in the focus of pain. The mechanism of pain elimination by these components is based on their ability to reduce the sensitivity of nerve endings to a variety of irritants (including mechanical and physiological ones). Paracetamol also affects the structural substances of the hypothalamus, so it is able to regulate the processes of thermoregulation.

The drug "Bol-Run" (tablets) is absorbed in the digestive tract for a very short time. The relationship of diclofenac with serum proteins is more than 99%, paracetamol - not less than 10%. The maximum concentration of active substances of the drug in the synovial fluid and blood is reached after 2-4 hours after admission.

The active substances and their metabolites have different terms and ways of excretion from the body. The half-life of diclofenac and its metabolites is about 1-3 hours. More than half of the total volume of this active substance is excreted through the organs of urination. The half-life of paracetamol and the metabolites formed is a maximum of 3 hours. Excretion of the compounds occurs mainly through the liver, and only 5% through the kidneys.

When using the drug "Bol-Run"

Consider a list of diseases and conditions in which the use of the drug "Bol-Run" is recommended. Tablets instruction advises to take with inflammatory diseases of the joints: rheumatism, osteoarthritis, gout, lumbago, rheumatoid and juvenile chronic arthritis, as well as with neuralgia and myalgia. In addition, the drug can be taken as an anesthetic for trauma (bruises, dislocations, fractures and burns).

In what other cases can I take Bol-Run tablets? The use of this drug is effective in almost any kind of pain of small or medium intensity, including dysmenorrhea (primary). Also, the medicine helps to get rid of toothache, migraine and fever, accompanying an inflammatory disease of an infectious origin.

Tablets "Bol-Run Premium" because of the components in their composition, it is advisable to take with a pronounced headache, pain in the muscles and joints of medium and strong intensity.

Methods of application and dosage

Scheme of taking the drug "Bol-Run" (tablets) recommends the instruction to be based on the patient's existing disease and its age. In the classical version of the drug take 2-3 times a day for one tablet. The duration of treatment of pain syndrome is always determined by a specialist. For chronic, not passing pains, it is recommended to take a maintenance dose of the drug - 1 tablet every two days. According to the same scheme, the drug "Bol-Ran Neo" is taken. Tablets instruction recommends drinking with a sufficient amount of water (not less than 0.5 cup).

Specialists draw the attention of patients to the fact that the maximum number of tablets taken per day should not exceed 4 pieces. In this case, the time interval between receptions should be at least 4 hours.

Contraindications for use

Contraindications, available for the preparation "Bol-Run", are due mainly to the negative effect of its components on the mucous membrane of the digestive system. Thus, tablets are not recommended for use in the treatment of pain in persons with peptic ulcer of the stomach and duodenum. Particular care should be taken and those who suffer from erosive diseases of the gastrointestinal tract.

In addition to the above contraindications to the use of the drug "Bol-Run" (tablets), the instruction mentions intolerance of some components of the drug. It is also not recommended to take it to people who at least once in their lifetime have suffered an allergic reaction to aspirin and other non-steroidal anti-inflammatory drugs. Such a reaction can occur in the form of bronchospasm, acute form of rhinitis or urticaria.

The Bol-Ran Premium tablets are not recommended for patients who have had a history of high blood pressure or sleep disturbances (due to the caffeine in their composition). This medicine is strictly contraindicated for those who suffer from hypertension.

The use of "Bol-Run" tablets by pregnant and nursing mothers

Pregnancy and the period of breastfeeding according to the instructions for use of the drug are serious contraindications to the use of the drug "Bol-Run Premium", "Bol-Ran Neo" and the usual "Bol-Run". The instruction advises if it is necessary to administer therapy with these medicines to temporarily stop breastfeeding. Concerning the gestation period, experts agree that the risk of the consequences of taking the medication for the fetus should not exceed the possible benefits for the mother.

Application of the drug in childhood

Tablets with analgesic and anti-inflammatory effect "Bol-Run" experts do not recommend to use for the treatment of children under the age of 14 years. This instruction must be strictly observed. As therapeutic agents in this case it is better to use other drugs with a similar mechanism of action.

An overdose of the drug: symptoms and treatment

If the recommended dosages and the regimen of the "Bol-Run" preparation in the form of tablets are not observed, the patient may develop an overdose. The same can occur in the treatment of pain by several drugs containing components such as paracetamol and diclofenac.

Symptomatically, an overdose can be expressed by attacks of severe headache, motor excitability, convulsions and dizziness. The patient may also be disturbed by nausea, vomiting, anorexia. Skin covers with excess in the body of paracetamol become pale. Taking a significant amount of the Bol-Run product within a few days can lead to necrosis of the liver cells. In addition, in isolated cases, an overdose provoked the development of renal failure.

Eliminating the effects of overdose is a symptomatic treatment. Immediately after the appearance of characteristic symptoms, the patient is rinsed with the stomach (if the drug was taken once in large quantities) and prescribed activated carbon or a solution of other sorbents. If liver tissue is involved, methionine and acetylcysteine may be required. In addition, the doctor can decide on the use of donors SH-group.

Side effects

Both active components of the "Bol-Run" tablets can cause unwanted reactions of the body. That's why the list of side effects of the medication is so wide. All information about these phenomena is set forth in the table below.

According to experts, side effects often appear when the recommendations for dosing the drug are not observed. Depth of organ damage also depends on how accurately the instruction for the use of the drug has been observed.

Drug Interactions

Doctors who prescribe the Bol-Run tablets to their patients should take into account a number of factors, including the ability of the drug to interact with other drugs. Very often, drug combinations are negative. If the recommendations described in the instructions are not followed, an overdose may occur or the effect produced by the preparations will be very weak.

What can the official instruction tell about this? "Bol-Run" ("Neo" or "Premium") can not be taken together with other non-steroidal anti-inflammatory drugs. This can lead to overdose and other complications. The same applies to drugs from the group of anticoagulants. This combination very often leads to the appearance of side effects associated with the organs of blood and cardiovascular system.

Particular attention should be paid to the patients' recommendations regarding the joint taking of the Bol-Run tablets with alcohol and drugs belonging to the barbiturate group. The paracetamol, which is part of the drug, together with ethyl alcohol, significantly increases its negative effect on liver cells.

When appointing this remedy, it is necessary to inform the doctor about all medicines taken within the last 2 weeks.

special instructions

Particular attention is required by patients who, at the time of the prescription of the Bol-Ran drug for oral administration, diagnosed disorders of kidney and liver function (including alcoholic origin), bile ducts, cardiovascular diseases. If the drug is administered according to unconditional indications, monitoring of the state of the kidneys, liver and cardiac activity is necessary throughout the duration of therapy.

Due to the fact that dizziness and drowsiness are mentioned among undesirable reactions of the body to this medication, it is not recommended to perform work at altitude, drive vehicles and manage complex mechanisms during the treatment of Bol-Run tablets.

Reviews about tablets "Bol-Run"

What do consumers and clinicians talk about the drug "Bol-Run"? Reviews about this medicine can be found often. Almost all of them are positive. Consumers speak of tablets as very effective. According to them, pain after taking medication was reduced within 30-50 minutes, and during the following 2 hours completely disappeared.

The fact that the drug has side effects that prevent its further admission, there is practically no feedback. There is also little information about overdose. According to experts, this is because most patients tend to trust doctors about their recommendations.